{"title":"il -22介导肿瘤细胞和免疫细胞之间的相互作用与人类结直肠癌预后良好相关","authors":"Raoul André Droeser, Giandomenica Iezzi","doi":"10.33696/immunology.3.087","DOIUrl":null,"url":null,"abstract":"<p><p>The positive prognostic role of the immune environment in colorectal cancer is widely accepted. However, there are few data about the prognostic significance of interleukin-22 in human colorectal cancer which is still debated. In our study we could demonstrate for the first time a positive prognostic role of interleukin-22 in human colorectal cancer relying on its capacity to induce in tumor cells the production of chemokines recruiting into the tumor microenvironment neutrophils associated with a favorable clinical outcome.</p>","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":"3 2","pages":"118-121"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611329/pdf/","citationCount":"2","resultStr":"{\"title\":\"IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer.\",\"authors\":\"Raoul André Droeser, Giandomenica Iezzi\",\"doi\":\"10.33696/immunology.3.087\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The positive prognostic role of the immune environment in colorectal cancer is widely accepted. However, there are few data about the prognostic significance of interleukin-22 in human colorectal cancer which is still debated. In our study we could demonstrate for the first time a positive prognostic role of interleukin-22 in human colorectal cancer relying on its capacity to induce in tumor cells the production of chemokines recruiting into the tumor microenvironment neutrophils associated with a favorable clinical outcome.</p>\",\"PeriodicalId\":73644,\"journal\":{\"name\":\"Journal of cellular immunology\",\"volume\":\"3 2\",\"pages\":\"118-121\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611329/pdf/\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of cellular immunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33696/immunology.3.087\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of cellular immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33696/immunology.3.087","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer.
The positive prognostic role of the immune environment in colorectal cancer is widely accepted. However, there are few data about the prognostic significance of interleukin-22 in human colorectal cancer which is still debated. In our study we could demonstrate for the first time a positive prognostic role of interleukin-22 in human colorectal cancer relying on its capacity to induce in tumor cells the production of chemokines recruiting into the tumor microenvironment neutrophils associated with a favorable clinical outcome.
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