Laura Ruiz-Azcona , Miguel Santibañez , Francisco Javier Roig , Hermelinda Vanaclocha , Maria Paz Ventero , Vicente Boix , Joaquín Portilla-Sogorb , José Sánchez-Paya , Esperanza Merino , Juan Carlos Rodriguez
{"title":"瓦伦西亚自治区大型医院中耳念珠菌的分离基于人群的研究(2013-2017)","authors":"Laura Ruiz-Azcona , Miguel Santibañez , Francisco Javier Roig , Hermelinda Vanaclocha , Maria Paz Ventero , Vicente Boix , Joaquín Portilla-Sogorb , José Sánchez-Paya , Esperanza Merino , Juan Carlos Rodriguez","doi":"10.1016/j.riam.2021.01.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p><span><em>Candida auris</em></span> is an emerging multidrug-resistant and highly virulent yeast that spreads easily among patients.</p></div><div><h3>Aims</h3><p><span>To describe the characteristics of candidemia caused by </span><em>C. auris</em> in the southeast of Spain (Autonomous Community of Valencia – ACV) through a 5-year population-based study.</p></div><div><h3>Methods</h3><p>An analysis of all the episodes of candidemia diagnosed in the ACV, with approximately 4,500,000 inhabitants, during 2013–2017, was done. Data were obtained from the Epidemiological Surveillance Valencian Network, a network that collects all the microbiological data from the hospitals in the study region.</p></div><div><h3>Results</h3><p>Based on the records, 1.9% of the isolates recovered from the positive blood cultures (corresponding to 1789 patients) were yeasts. This implies an annual rate of 7.09 cases/100,000 inhabitants. Of the 23 yeast species isolated, <span><em>Candida albicans</em></span> was the most frequent (37.3%), showing a higher frequency than <span><em>Candida parapsilosis</em></span> (28.4%) and <span><em>Candida glabrata</em></span> (15.6%) (<em>p</em> <!--><<!--> <!-->0.0001). It is remarkable the emergence of <em>C. auris</em> during 2016 and 2017, as this species became the fourth more prevalent in 2016 (9.2%), and the third in 2017 (15.7%). Fungemia was more common in hospitals with >500 beds (63.3% versus 36.7% in small hospitals) (<em>p</em> <!--><<!--> <!-->0.0001), and <em>C. auris</em> was mostly isolated in large hospitals (8.5% versus 0.3%); its incidence was higher in autumn and among the age group of 65–84 years.</p></div><div><h3>Conclusions</h3><p>The information about the local epidemiology of candidemia is essential in order to decide the best empirical treatment approach. This study reports the novel presence of <em>C. auris</em> in large hospitals. This pathogen has usually resistance to several antifungals and causes severe fungemia, so the results of this work reveal the need to monitor the presence of this species systematically.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.riam.2021.01.005","citationCount":"2","resultStr":"{\"title\":\"Isolation of Candida auris in large hospitals in the Autonomous Community of Valencia; population-based study (2013–2017)\",\"authors\":\"Laura Ruiz-Azcona , Miguel Santibañez , Francisco Javier Roig , Hermelinda Vanaclocha , Maria Paz Ventero , Vicente Boix , Joaquín Portilla-Sogorb , José Sánchez-Paya , Esperanza Merino , Juan Carlos Rodriguez\",\"doi\":\"10.1016/j.riam.2021.01.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p><span><em>Candida auris</em></span> is an emerging multidrug-resistant and highly virulent yeast that spreads easily among patients.</p></div><div><h3>Aims</h3><p><span>To describe the characteristics of candidemia caused by </span><em>C. auris</em> in the southeast of Spain (Autonomous Community of Valencia – ACV) through a 5-year population-based study.</p></div><div><h3>Methods</h3><p>An analysis of all the episodes of candidemia diagnosed in the ACV, with approximately 4,500,000 inhabitants, during 2013–2017, was done. Data were obtained from the Epidemiological Surveillance Valencian Network, a network that collects all the microbiological data from the hospitals in the study region.</p></div><div><h3>Results</h3><p>Based on the records, 1.9% of the isolates recovered from the positive blood cultures (corresponding to 1789 patients) were yeasts. This implies an annual rate of 7.09 cases/100,000 inhabitants. Of the 23 yeast species isolated, <span><em>Candida albicans</em></span> was the most frequent (37.3%), showing a higher frequency than <span><em>Candida parapsilosis</em></span> (28.4%) and <span><em>Candida glabrata</em></span> (15.6%) (<em>p</em> <!--><<!--> <!-->0.0001). It is remarkable the emergence of <em>C. auris</em> during 2016 and 2017, as this species became the fourth more prevalent in 2016 (9.2%), and the third in 2017 (15.7%). Fungemia was more common in hospitals with >500 beds (63.3% versus 36.7% in small hospitals) (<em>p</em> <!--><<!--> <!-->0.0001), and <em>C. auris</em> was mostly isolated in large hospitals (8.5% versus 0.3%); its incidence was higher in autumn and among the age group of 65–84 years.</p></div><div><h3>Conclusions</h3><p>The information about the local epidemiology of candidemia is essential in order to decide the best empirical treatment approach. This study reports the novel presence of <em>C. auris</em> in large hospitals. This pathogen has usually resistance to several antifungals and causes severe fungemia, so the results of this work reveal the need to monitor the presence of this species systematically.</p></div>\",\"PeriodicalId\":21291,\"journal\":{\"name\":\"Revista Iberoamericana De Micologia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2021-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.riam.2021.01.005\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Iberoamericana De Micologia\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1130140621000115\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MYCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Iberoamericana De Micologia","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1130140621000115","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MYCOLOGY","Score":null,"Total":0}
Isolation of Candida auris in large hospitals in the Autonomous Community of Valencia; population-based study (2013–2017)
Background
Candida auris is an emerging multidrug-resistant and highly virulent yeast that spreads easily among patients.
Aims
To describe the characteristics of candidemia caused by C. auris in the southeast of Spain (Autonomous Community of Valencia – ACV) through a 5-year population-based study.
Methods
An analysis of all the episodes of candidemia diagnosed in the ACV, with approximately 4,500,000 inhabitants, during 2013–2017, was done. Data were obtained from the Epidemiological Surveillance Valencian Network, a network that collects all the microbiological data from the hospitals in the study region.
Results
Based on the records, 1.9% of the isolates recovered from the positive blood cultures (corresponding to 1789 patients) were yeasts. This implies an annual rate of 7.09 cases/100,000 inhabitants. Of the 23 yeast species isolated, Candida albicans was the most frequent (37.3%), showing a higher frequency than Candida parapsilosis (28.4%) and Candida glabrata (15.6%) (p < 0.0001). It is remarkable the emergence of C. auris during 2016 and 2017, as this species became the fourth more prevalent in 2016 (9.2%), and the third in 2017 (15.7%). Fungemia was more common in hospitals with >500 beds (63.3% versus 36.7% in small hospitals) (p < 0.0001), and C. auris was mostly isolated in large hospitals (8.5% versus 0.3%); its incidence was higher in autumn and among the age group of 65–84 years.
Conclusions
The information about the local epidemiology of candidemia is essential in order to decide the best empirical treatment approach. This study reports the novel presence of C. auris in large hospitals. This pathogen has usually resistance to several antifungals and causes severe fungemia, so the results of this work reveal the need to monitor the presence of this species systematically.
期刊介绍:
Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.