瓦伦西亚自治区大型医院中耳念珠菌的分离基于人群的研究(2013-2017)

IF 1.5 4区 生物学 Q4 MYCOLOGY
Laura Ruiz-Azcona , Miguel Santibañez , Francisco Javier Roig , Hermelinda Vanaclocha , Maria Paz Ventero , Vicente Boix , Joaquín Portilla-Sogorb , José Sánchez-Paya , Esperanza Merino , Juan Carlos Rodriguez
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引用次数: 2

摘要

背景耳念珠菌是一种新兴的多重耐药和高毒力酵母菌,很容易在患者中传播。目的通过一项为期5年的人群研究,了解西班牙东南部(瓦伦西亚自治区- ACV)由金黄色葡萄球菌引起的念珠菌病的特点。方法对2013-2017年期间ACV中诊断出的所有念珠菌发作进行分析,其中约有450万居民。数据来自流行病学监测瓦伦西亚网络,该网络收集了研究地区医院的所有微生物数据。结果从阳性血培养(对应于1789例患者)中回收的分离株中有1.9%为酵母菌。这意味着年发病率为7.09例/10万居民。在分离到的23种酵母菌中,以白色念珠菌最多(37.3%),其频率高于假丝酵母菌(28.4%)和光丝酵母菌(15.6%)(p <0.0001)。值得注意的是,2016年和2017年,金黄色葡萄球菌的流行率分别为9.2%和15.7%,居第四位和第三位。真菌病在500张床位的医院中更为常见(63.3%比36.7%)(p <0.0001),耳球菌主要在大型医院分离(8.5%对0.3%);其发病率在秋季和65-84岁年龄组较高。结论了解当地念珠菌的流行病学信息对确定最佳的经验性治疗方案至关重要。本研究报道了大型医院中金黄色葡萄球菌的新存在。这种病原体通常对几种抗真菌药物具有耐药性,并引起严重的真菌血症,因此本工作的结果表明需要系统地监测该物种的存在。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Isolation of Candida auris in large hospitals in the Autonomous Community of Valencia; population-based study (2013–2017)

Background

Candida auris is an emerging multidrug-resistant and highly virulent yeast that spreads easily among patients.

Aims

To describe the characteristics of candidemia caused by C. auris in the southeast of Spain (Autonomous Community of Valencia – ACV) through a 5-year population-based study.

Methods

An analysis of all the episodes of candidemia diagnosed in the ACV, with approximately 4,500,000 inhabitants, during 2013–2017, was done. Data were obtained from the Epidemiological Surveillance Valencian Network, a network that collects all the microbiological data from the hospitals in the study region.

Results

Based on the records, 1.9% of the isolates recovered from the positive blood cultures (corresponding to 1789 patients) were yeasts. This implies an annual rate of 7.09 cases/100,000 inhabitants. Of the 23 yeast species isolated, Candida albicans was the most frequent (37.3%), showing a higher frequency than Candida parapsilosis (28.4%) and Candida glabrata (15.6%) (p < 0.0001). It is remarkable the emergence of C. auris during 2016 and 2017, as this species became the fourth more prevalent in 2016 (9.2%), and the third in 2017 (15.7%). Fungemia was more common in hospitals with >500 beds (63.3% versus 36.7% in small hospitals) (p < 0.0001), and C. auris was mostly isolated in large hospitals (8.5% versus 0.3%); its incidence was higher in autumn and among the age group of 65–84 years.

Conclusions

The information about the local epidemiology of candidemia is essential in order to decide the best empirical treatment approach. This study reports the novel presence of C. auris in large hospitals. This pathogen has usually resistance to several antifungals and causes severe fungemia, so the results of this work reveal the need to monitor the presence of this species systematically.

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来源期刊
CiteScore
1.90
自引率
0.00%
发文量
17
审稿时长
81 days
期刊介绍: Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.
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