多发性硬化症的疾病生物标志物:当前血清神经丝轻链的观点。

IF 2.3 Q3 CLINICAL NEUROLOGY
Neurodegenerative disease management Pub Date : 2021-08-01 Epub Date: 2021-07-01 DOI:10.2217/nmt-2020-0058
Dejan Jakimovski, Michael G Dwyer, Niels Bergsland, Bianca Weinstock-Guttman, Robert Zivadinov
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引用次数: 4

摘要

多发性硬化症(MS)持续的神经炎症和神经退行性病理导致身体和认知障碍的不可逆积累。可靠的MS疾病过程早期检测有助于MS患者的诊断、监测和治疗管理。最近的分析技术进步现在允许可靠的定量血清为基础的神经丝轻链(sNfL)水平,它提供了关于神经轴突损伤程度的时间信息。本文综述了sNfL与临床和认知结局、其他临床旁措施和治疗反应的关系和预测价值。sNfL测量是一种新兴的、无创的和疾病反应性的MS生物标志物,目前用于研究和临床试验环境。了解sNfL混杂因素和进一步的检测标准化将允许该生物标志物的临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Disease biomarkers in multiple sclerosis: current serum neurofilament light chain perspectives.

The continuous neuroinflammatory and neurodegenerative pathology in multiple sclerosis (MS) results in irreversible accumulation of physical and cognitive disability. Reliable early detection of MS disease processes can aid in the diagnosis, monitoring and treatment management of MS patients. Recent assay technological advancements now allow reliable quantification of serum-based neurofilament light chain (sNfL) levels, which provide temporal information regarding the degree of neuroaxonal damage. The relationship and predictive value of sNfL with clinical and cognitive outcomes, other paraclinical measures and treatment response is reviewed. sNfL measurement is an emerging, noninvasive and disease-responsive MS biomarker that is currently utilized in research and clinical trial settings. Understanding sNfL confounders and further assay standardization will allow clinical implementation of this biomarker.

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CiteScore
4.30
自引率
0.00%
发文量
35
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