外泌体来源的microrna分析揭示了乳腺癌、前列腺癌和胶质母细胞瘤癌细胞侵袭过程中的细胞间通讯。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Francesca Lessi, Paolo Aretini, Milena Rizzo, Mariangela Morelli, Michele Menicagli, Sara Franceschi, Chiara Maria Mazzanti
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引用次数: 4

摘要

miRNA代表了一种在许多病理条件下调节基因表达的机制。已知外泌体由所有类型的细胞分泌,外泌体释放的分子是调节细胞过程的关键信使。我们研究了癌症细胞在侵袭过程中释放的外泌体的miRNA含量。癌症细胞系(胶质母细胞瘤、乳腺癌和前列腺癌)的融合细胞上产生的划痕产生了入侵刺激。研究发现,在细胞侵袭过程中,几种miRNA的丰度存在显著差异,既在不同细胞系中常见,也具有排他性。了解参与入侵的细胞中的语言代码可以开发出抑制细胞通信、减缓或最终停止其活动的疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells.

Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells.

Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells.

Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells.

MiRNAs represent a mechanism that regulates gene expression in many pathological conditions. Exosomes are known to be secreted from all types of cells, and the exosomes-released molecules are crucial messengers that can regulate cellular processes. We investigated the miRNAs content of exosomes released by cancer cells during the invasion . An invasion stimulus has been generated through scratches created on the confluent cells of cancer cell lines: glioblastoma, breast and prostate cancers.Several miRNAs were found to be significantly differentially abundant during the cell invasion , both in common among different cell lines and exclusive. Understanding the language codes among cells involved in invasion can lead to the development of therapies that can inhibit cellular communication, slowing or eventually stopping their activity.

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CiteScore
7.20
自引率
4.30%
发文量
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