DNA复制胁迫、染色质动力学和DNA损伤反应对维持基因组稳定性的相互作用

IF 6.4 2区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Mutation Research-Reviews in Mutation Research Pub Date : 2021-01-01 DOI:10.1016/j.mrrev.2020.108346

Maddalena Mognato , Susanne Burdak-Rothkamm , Kai Rothkamm

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引用次数: 15

摘要

DNA复制应激是DNA损伤的主要来源，包括促进DNA损伤反应(DDR)信号的双链断裂。这种损伤的无效修复会影响基因组的完整性。在DNA复制过程中，不同的因子以协调的方式作用于染色质重塑。虽然最近的研究强调了相互作用的个体分子机制，但对复制应激下染色质变化的协调却知之甚少。在这篇综述中，我们试图探讨哺乳动物细胞中DNA复制应激、DDR和基因组完整性之间的复杂关系，并考虑到染色质配置作为DNA修复的重要调节剂的作用。本文综述了DNA复制胁迫后染色质恢复和表观遗传重建的最新研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability

DNA replication stress is a major source of DNA damage, including double-stranded breaks that promote DNA damage response (DDR) signaling. Inefficient repair of such lesions can affect genome integrity. During DNA replication different factors act on chromatin remodeling in a coordinated way. While recent studies have highlighted individual molecular mechanisms of interaction, less is known about the orchestration of chromatin changes under replication stress. In this review we attempt to explore the complex relationship between DNA replication stress, DDR and genome integrity in mammalian cells, taking into account the role of chromatin disposition as an important modulator of DNA repair. Recent data on chromatin restoration and epigenetic re-establishment after DNA replication stress are reviewed.

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来源期刊

Mutation Research-Reviews in Mutation Research 生物-毒理学

CiteScore

12.20

自引率

1.90%

发文量

审稿时长

15.7 weeks

期刊介绍： The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.