婴儿alk -1阴性间变性大细胞淋巴瘤表现为硬脑膜肿块。

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY

Clinical Neuropathology Pub Date : 2021-11-01 DOI:10.5414/NP301395

Nishtha Ahuja, Rahul Sharma, Kirti Gupta, Karalanglin Tiewsoh, Pravin Salunke, Chandrashekhar Gendle, Richa Jain, Amita Trehan

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引用次数: 0

摘要

间变性大细胞淋巴瘤(ALCL)很少发生在小儿中枢神经系统。病例介绍:我们描述了一个诊断具有挑战性的情况下，11个月大的婴儿呈现脑神经麻痹和周围嗜酸性粒细胞增多。影像学显示脑膜增厚，增强，硬脑膜沉积，活检组织学和免疫表型分析显示ALK-1阴性ALCL的特征。彻底的调查排除了任何颅外起源的可能性。因此，诊断为“原发性”ALCL。结论:据我们所知，在婴儿硬脑膜中出现的ALCL还没有被描述过。

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ALK-1-negative anaplastic large-cell lymphoma presenting as a dura-based mass in an infant.

Introduction: Anaplastic large-cell lymphoma (ALCL) rarely occurs in the central nervous system in the pediatric population.

Case presentation: We describe a diagnostically challenging case of an 11-month-old infant presenting with cranial nerve palsies and peripheral eosinophilia. Imaging demonstrated meningeal thickening with enhancement and dura-based deposits, the biopsy of which revealed features of ALK-1 negative ALCL on histologic and immunophenotypic analysis. A thorough investigation excluded the possibility of any extra-cranial origin. Hence, a diagnosis of "primary" ALCL was rendered.

Conclusion: ALCL arising in the dura in an infant has not been described earlier, to the best of our knowledge.

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来源期刊

Clinical Neuropathology 医学-病理学

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Clinical Neuropathology appears bi-monthly and publishes reviews and editorials, original papers, short communications and reports on recent advances in the entire field of clinical neuropathology. Papers on experimental neuropathologic subjects are accepted if they bear a close relationship to human diseases. Correspondence (letters to the editors) and current information including book announcements will also be published.