难治性类风湿关节炎的患病率和预测因素:KURAMA队列。

IF 2.7 Q3 IMMUNOLOGY
Immunological Medicine Pub Date : 2022-03-01 Epub Date: 2021-05-25 DOI:10.1080/25785826.2021.1928383
Ryu Watanabe, Motomu Hashimoto, Koichi Murata, Kosaku Murakami, Masao Tanaka, Koichiro Ohmura, Hiromu Ito, Shuichi Matsuda
{"title":"难治性类风湿关节炎的患病率和预测因素:KURAMA队列。","authors":"Ryu Watanabe,&nbsp;Motomu Hashimoto,&nbsp;Koichi Murata,&nbsp;Kosaku Murakami,&nbsp;Masao Tanaka,&nbsp;Koichiro Ohmura,&nbsp;Hiromu Ito,&nbsp;Shuichi Matsuda","doi":"10.1080/25785826.2021.1928383","DOIUrl":null,"url":null,"abstract":"<p><p>Difficult-to-treat rheumatoid arthritis (D2T RA) is a multifactorial condition in which disease activity of RA persists despite consecutive treatment with biological or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs). To evaluate the prevalence and predictive risk factors of D2T RA in our institution, a single-center, retrospective study was conducted. Medical records of RA patients, who visited our hospital from 2011 to 2020 and had a follow-up of more than 6 months, were retrospectively reviewed. D2T RA was defined as RA with a disease activity score of 28 - erythrocyte sedimentation rate (DAS28-ESR) of 3.2 or higher at the last visit, despite the use of at least two b/tsDMARDs. A logistic regression model was used to identify risk factors. A total of 672 patients were enrolled. The mean age at disease onset was 52.1 years and females were dominant (76.3%). After a mean follow-up of 46.6 months, patients with D2T RA accounted for 7.9% of overall patients. Multivariate analysis identified high rheumatoid factor (RF) levels (≥156.4 IU/mL, odds ratio [OR]: 1.95), DAS28-ESR (OR: 1.24), and coexisting pulmonary disease (OR: 2.03) as predictive risk factors of D2T RA. In conclusion, high RF levels, high DAS28-ESR, and coexisting pulmonary disease at baseline can predict the development of D2T RA.</p>","PeriodicalId":37286,"journal":{"name":"Immunological Medicine","volume":"45 1","pages":"35-44"},"PeriodicalIF":2.7000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/25785826.2021.1928383","citationCount":"16","resultStr":"{\"title\":\"Prevalence and predictive factors of difficult-to-treat rheumatoid arthritis: the KURAMA cohort.\",\"authors\":\"Ryu Watanabe,&nbsp;Motomu Hashimoto,&nbsp;Koichi Murata,&nbsp;Kosaku Murakami,&nbsp;Masao Tanaka,&nbsp;Koichiro Ohmura,&nbsp;Hiromu Ito,&nbsp;Shuichi Matsuda\",\"doi\":\"10.1080/25785826.2021.1928383\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Difficult-to-treat rheumatoid arthritis (D2T RA) is a multifactorial condition in which disease activity of RA persists despite consecutive treatment with biological or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs). To evaluate the prevalence and predictive risk factors of D2T RA in our institution, a single-center, retrospective study was conducted. Medical records of RA patients, who visited our hospital from 2011 to 2020 and had a follow-up of more than 6 months, were retrospectively reviewed. D2T RA was defined as RA with a disease activity score of 28 - erythrocyte sedimentation rate (DAS28-ESR) of 3.2 or higher at the last visit, despite the use of at least two b/tsDMARDs. A logistic regression model was used to identify risk factors. A total of 672 patients were enrolled. The mean age at disease onset was 52.1 years and females were dominant (76.3%). After a mean follow-up of 46.6 months, patients with D2T RA accounted for 7.9% of overall patients. Multivariate analysis identified high rheumatoid factor (RF) levels (≥156.4 IU/mL, odds ratio [OR]: 1.95), DAS28-ESR (OR: 1.24), and coexisting pulmonary disease (OR: 2.03) as predictive risk factors of D2T RA. In conclusion, high RF levels, high DAS28-ESR, and coexisting pulmonary disease at baseline can predict the development of D2T RA.</p>\",\"PeriodicalId\":37286,\"journal\":{\"name\":\"Immunological Medicine\",\"volume\":\"45 1\",\"pages\":\"35-44\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2022-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/25785826.2021.1928383\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunological Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/25785826.2021.1928383\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/5/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunological Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/25785826.2021.1928383","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/5/25 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 16

摘要

难治性类风湿关节炎(D2T RA)是一种多因素疾病,尽管连续使用生物或靶向合成疾病改善抗风湿药物(b/tsDMARDs)治疗,RA的疾病活动仍持续存在。为了评估我院D2T类RA的患病率及预测危险因素,我们进行了一项单中心回顾性研究。回顾性分析2011年至2020年在我院就诊、随访6个月以上的RA患者的病历。D2T类RA定义为疾病活动性评分为28-最后一次就诊时红细胞沉降率(DAS28-ESR)为3.2或更高,尽管使用了至少2个b/ tsdmard。采用logistic回归模型识别危险因素。共有672名患者入组。平均发病年龄52.1岁,以女性为主(76.3%)。平均随访46.6个月后,D2T RA患者占总患者的7.9%。多因素分析发现,高风湿因子(RF)水平(≥156.4 IU/mL,优势比[OR]: 1.95)、DAS28-ESR (OR: 1.24)和合并肺部疾病(OR: 2.03)是D2T类风湿性关节炎的预测危险因素。综上所述,高RF水平、高DAS28-ESR和基线时共存肺部疾病可预测D2T RA的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence and predictive factors of difficult-to-treat rheumatoid arthritis: the KURAMA cohort.

Difficult-to-treat rheumatoid arthritis (D2T RA) is a multifactorial condition in which disease activity of RA persists despite consecutive treatment with biological or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs). To evaluate the prevalence and predictive risk factors of D2T RA in our institution, a single-center, retrospective study was conducted. Medical records of RA patients, who visited our hospital from 2011 to 2020 and had a follow-up of more than 6 months, were retrospectively reviewed. D2T RA was defined as RA with a disease activity score of 28 - erythrocyte sedimentation rate (DAS28-ESR) of 3.2 or higher at the last visit, despite the use of at least two b/tsDMARDs. A logistic regression model was used to identify risk factors. A total of 672 patients were enrolled. The mean age at disease onset was 52.1 years and females were dominant (76.3%). After a mean follow-up of 46.6 months, patients with D2T RA accounted for 7.9% of overall patients. Multivariate analysis identified high rheumatoid factor (RF) levels (≥156.4 IU/mL, odds ratio [OR]: 1.95), DAS28-ESR (OR: 1.24), and coexisting pulmonary disease (OR: 2.03) as predictive risk factors of D2T RA. In conclusion, high RF levels, high DAS28-ESR, and coexisting pulmonary disease at baseline can predict the development of D2T RA.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Immunological Medicine
Immunological Medicine Medicine-Immunology and Allergy
CiteScore
7.10
自引率
2.30%
发文量
19
审稿时长
19 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信