新疆阿魏树脂含亚砜衍生物的研究。

IF 2.1 4区医学 Q3 CHEMISTRY, MEDICINAL

Planta medica Pub Date : 2022-05-01 Epub Date: 2021-05-20 DOI:10.1055/a-1495-5963

Junchi Wang, Haoli Yan, Xiaoshuang Huo, Lingyu Li, Huijuan Wang, Meng Zhang, Xiaojin Li, Yaqin Zhao, Gang Chen, Jianyong Si

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引用次数: 3

摘要

从新疆阿Ferula sinkiangenoxide树脂中分离得到4个未描述的含亚砜衍生物，分别为sinkiangen氧化物A和B、(2Z, 4E)-sinkiangenoxide C和(2E, 4E)-sinkiangenoxide C(1∶- 4∶)，以及1-(甲基硫)丙基(E)-1-丙烯二硫化物(5∶)。通过红外、紫外、hresms、NMR和CD等光谱分析方法确定了它们的结构。化合物2:~ 4:对4种人癌细胞具有中等的细胞毒活性，IC50值在15.0 ~ 40.3µM之间。杏青素B(2:)可诱导HepG2细胞凋亡。此外，化合物5:有效减弱脂多糖诱导的一氧化氮释放和TNF-α、IL-1β、IL-6和IL-10的表达。

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New Sulfoxide-Containing Derivatives from the Resin of Ferula sinkiangensis.

Four undescribed sulfoxide-containing derivatives, sinkiangenoxides A and B, (2Z, 4E)-sinkiangenoxide C, and (2E, 4E)-sinkiangenoxide C (1: - 4: ), and one known compound, 1-(methylthio)propyl (E)-1-propenyl disulfide (5: ), were isolated from the resin of Ferula sinkiangensis. Their structures were determined based on spectroscopic methods, including IR, UV, HRESIMS, NMR, and CD analysis. Compounds 2: - 4: showed moderate cytotoxic activities against four human cancer cell lines with IC₅₀ values ranging from 15.0 to 40.3 µM. Sinkiangenoxide B (2: ) was shown to induce apoptosis in HepG2 cells. In addition, compound 5: effectively attenuated lipopolysaccharide-induced nitric oxide release and TNF-α, IL-1β, IL-6, and IL-10 expression.

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来源期刊

Planta medica 医学-药学

CiteScore

5.10

自引率

3.70%

发文量

101

审稿时长

1.8 months

期刊介绍： Planta Medica is one of the leading international journals in the field of natural products – including marine organisms, fungi as well as micro-organisms – and medicinal plants. Planta Medica accepts original research papers, reviews, minireviews and perspectives from researchers worldwide. The journal publishes 18 issues per year. The following areas of medicinal plants and natural product research are covered: -Biological and Pharmacological Activities -Natural Product Chemistry & Analytical Studies -Pharmacokinetic Investigations -Formulation and Delivery Systems of Natural Products. The journal explicitly encourages the submission of chemically characterized extracts.