含有凝固芽孢杆菌、鼠李糖乳杆菌、嗜酸乳杆菌和低聚果糖的共生补充剂对2型糖尿病患者有良好的效果吗?一项随机、双盲、安慰剂对照试验。

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2023-12-01 Epub Date: 2021-06-02 DOI:10.1080/13813455.2021.1928225

Aynaz Velayati, Iman Kareem, Meghdad Sedaghat, Golbon Sohrab, Omid Nikpayam, Mehdi Hedayati, Khadijeh Abhari, Ehsan Hejazi

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引用次数: 11

摘要

本研究旨在确定补充凝固芽孢杆菌共生菌对2型糖尿病患者代谢因子和炎症的影响。在这项临床试验中，50名2型糖尿病患者被随机分配到共生组(含有凝固芽孢杆菌+鼠李糖乳杆菌+嗜酸乳杆菌和低聚果糖)或安慰剂组，每天服用一袋，持续12周。在研究开始和结束时测量血糖指数、血脂和hs-CRP。协方差分析表明，在2型糖尿病患者中补充空腹血糖(FBG)、胰岛素、胰岛素抵抗稳态模型评估(HOMA- ir)、β-细胞功能(HOMA-β) (p p)可以改善代谢因子和炎症。

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Does symbiotic supplementation which contains Bacillus Coagulans Lactobacillus rhamnosus, Lactobacillus acidophilus and fructooligosaccharide has favourite effects in patients with type-2 diabetes? A randomised, double-blind, placebo-controlled trial.

This study aimed to determine the effect of Bacillus Coagulans symbiotic supplementation on metabolic factors and inflammation in patients with type-2 diabetes. In this clinical trial, 50 patients with type-2 diabetes were randomly assigned to the symbiotic (containing Bacillus Coagulans + Lactobacillus rhamnosus + Lactobacillus acidophilus and fructooligosaccharide) or placebo groups to receive one sachet daily for 12 weeks. Glycaemic Index, lipid profile, and hs-CRP were measured at the beginning and end of the study. Analysis of covariance demonstrated that fasting blood glucose (FBG), insulin, homeostatic Model Assessment for Insulin Resistance (HOMA-IR), β-cell function (HOMA-β) (p <.05) and hs-CRP (p <.05) significantly declined in the treatment group compared with the placebo group. So, the current study indicated that Bacillus Coagulans symbiotic supplementation could improve metabolic factors and inflammation in patients with type-2 diabetes.

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.