蛇尾藤茎提取物对高果糖/链脲佐菌素诱导的2型糖尿病大鼠具有强大的抗氧化和降糖作用。UHPLC-ESI-QTOF-MS技术对生物活性化合物的研究。

IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Opeyemi Joshua Olatunji, Jian Zuo, Oladipupo Odunayo Olatunde
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引用次数: 11

摘要

糖尿病是当代最致命、最普遍的代谢性疾病。本研究评估了尾叶莲提取物(SIE)对高果糖/链脲佐菌素诱导的2型糖尿病的抗糖尿病、抗氧化和胰腺保护作用。将SIE(50、100和200 mg/kg)分别给予糖尿病大鼠8周,观察SIE对糖尿病大鼠血糖指标、胰岛β细胞功能、血脂、肝肾功能和抗氧化指标的影响。结果表明,在干预结束时,SIE治疗可显著降低血糖、脂质参数、肝肾功能参数和脂质过氧化。此外,血清胰岛素水平显著升高,这是H&E染色中胰腺β细胞恢复的结果。此外,SIE还上调了糖尿病大鼠的血清抗氧化酶活性。结果表明,SIE具有有效的降血糖、降血脂和抗氧化作用,可显著恢复胰腺β细胞功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Securidaca inappendiculata stem extract confers robust antioxidant and antidiabetic effects against high fructose/streptozotocin induced type 2 diabetes in rats. Exploration of bioactive compounds using UHPLC-ESI-QTOF-MS.

Diabetes mellitus is the most deadly and most prevalent metabolic disease of contemporary times. This study evaluated the antidiabetic, antioxidant, and pancreato-protective effects of Securidaca inappendiculata extract (SIE) in high-fructose/streptozotocin-induced type 2 diabetes. SIE (50, 100, and 200 mg/kg) was administered to diabetic rats for 8 weeks, thereafter glycaemic parameters, pancreatic β cell function, lipid profile, hepatorenal function, and antioxidant parameters were evaluated in diabetic rats treated SIE. The results indicated that treatment with SIE markedly lowered blood glucose, lipid parameters, hepatorenal function parameters, and lipid peroxidation at the end of the intervention. Additionally, serum insulin levels were significantly increased as supported by restoration of pancreatic β-cell cells in the H&E staining. Moreover, SIE also upregulated serum antioxidant enzyme activities in the treated diabetic rats. The results revealed that SIE possesses potent antihyperglycemic and antihyperlipidemic and antioxidant effects with the considerable restoration of pancreatic β-cells function.

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来源期刊
Archives of Physiology and Biochemistry
Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY
CiteScore
6.90
自引率
3.30%
发文量
21
期刊介绍: Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.
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