非中枢神经系统儿童癌症幸存者的工作记忆网络及其与工作记忆表现的关系。

IF 1.6 4区 心理学 Q3 PSYCHOLOGY
Valerie Siegwart, Leonie Steiner, Manuela Pastore-Wapp, Valentin Benzing, Janine Spitzhuttl, Mirko Schmidt, Claus Kiefer, Nedelina Slavova, Michael Grotzer, Claudia Roebers, Maja Steinlin, Kurt Leibundgut, Regula Everts
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引用次数: 1

摘要

儿童癌症及其治疗使幸存者面临工作记忆能力低下的风险。工作记忆是一种核心的认知功能,在日常生活和学术任务中至关重要。本功能性核磁共振成像(fMRI)研究的目的是检查无中枢神经系统(CNS)参与的儿童癌症幸存者的工作记忆网络及其与认知表现的关系。30名幸存者(年龄7-16岁,癌症治疗后≥1年)和30名健康对照者在MRI期间进行了视觉空间工作记忆任务,包括低要求和高要求条件。工作记忆表现是通过扫描仪外的标准化测试来评估的。当认知需求增加时,幸存者的表现比对照组差,并显示出与工作记忆相关的轻微非典型激活的证据。与低要求工作记忆条件相比,幸存者组在高要求工作记忆条件下表现出右半球上顶叶(SPL)的过度激活,同时保持了他们的表现水平。幸存者右侧SPL的过度激活与扫描仪外较差的工作记忆表现相吻合。即使在没有中枢神经系统参与的儿童癌症幸存者中,我们发现神经标记指向大脑工作记忆网络的晚期效应。缩写sfmri:功能性磁共振成像;CNS:中枢神经系统;蒙特利尔神经学研究所;SES:社会经济地位;SPL:上顶叶。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Working Memory Network and Its Association with Working Memory Performance in Survivors of non-CNS Childhood Cancer.

Childhood cancer and its treatment puts survivors at risk of low working memory capacity. Working memory represents a core cognitive function, which is crucial in daily life and academic tasks. The aim of this functional MRI (fMRI) study was to examine the working memory network of survivors of childhood cancer without central nervous system (CNS) involvement and its relation to cognitive performance. Thirty survivors (aged 7-16 years, ≥ 1 year after cancer treatment) and 30 healthy controls performed a visuospatial working memory task during MRI, including a low- and a high-demand condition. Working memory performance was assessed using standardized tests outside the scanner. When cognitive demands increased, survivors performed worse than controls and showed evidence for slightly atypical working memory-related activation. The survivor group exhibited hyperactivation in the right-hemispheric superior parietal lobe (SPL) in the high- compared to the low-demand working memory condition, while maintaining their performance levels. Hyperactivation in the right SPL coincided with poorer working memory performance outside the scanner in survivors. Even in survivors of childhood cancer without CNS involvement, we find neural markers pointing toward late effects in the cerebral working memory network.AbbreviationsfMRI: Functional magnetic resonance imaging; CNS: Central nervous system; MNI: Montreal Neurological Institute; SES: Socioeconomic status; SPL: Superior parietal lobe.

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来源期刊
CiteScore
2.80
自引率
6.70%
发文量
17
审稿时长
>12 weeks
期刊介绍: Devoted to exploring relationships between brain and behavior across the life span, Developmental Neuropsychology publishes scholarly papers on the appearance and development of behavioral functions, such as language, perception, and social, motivational and cognitive processes as they relate to brain functions and structures. Appropriate subjects include studies of changes in cognitive function—brain structure relationships across a time period, early cognitive behaviors in normal and brain-damaged children, plasticity and recovery of function after early brain damage, the development of complex cognitive and motor skills, and specific and nonspecific disturbances, such as learning disabilities, mental retardation, schizophrenia, stuttering, and developmental aphasia. In the gerontologic areas, relevant subjects include neuropsychological analyses of normal age-related changes in brain and behavioral functions, such as sensory, motor, cognitive, and adaptive abilities; studies of age-related diseases of the nervous system; and recovery of function in later life. Empirical studies, research reviews, case reports, critical commentaries, and book reviews are featured in each issue. By publishing both basic and clinical studies of the developing and aging brain, the journal encourages additional scholarly work that advances understanding of the field of lifespan developmental neuropsychology.
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