Alejandro Martín-Quirós, Charbel Maroun-Eid, José Avendaño-Ortiz, Roberto Lozano-Rodríguez, Jaime Valentín Quiroga, Verónica Terrón, Karla Montalbán-Hernández, Miguel A García-Garrido, Elena Muñoz Del Val, Álvaro Del Balzo-Castillo, Carolina Rubio, Carolina Cubillos-Zapata, Luis A Aguirre, Eduardo López-Collazo
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引用次数: 0
摘要
我们报告了一对感染了 SARS-CoV-2 的夫妇从入院到出院（患者 1）以及从入院到出院和康复（患者 2）的不同临床进展情况，这些进展基于他们血液中的免疫检查点（IC）水平和免疫细胞分布。图中显示了详细的临床随访以及对免疫表型和 IC 水平的纵向分析。患者 1 中可溶性 IC 配体 galectin-9 (Gal-9) 的持续增加和 T 细胞中 T 细胞免疫球蛋白和含粘蛋白结构域的 3 (TIM-3) 蛋白的增加表明，Gal-9/TIM-3 轴被激活，随后该患者出现了潜在的细胞衰竭，而患者 2 却没有出现这种情况。我们的数据表明，在这种临床环境下，Gal-9/TIM-3 轴可能是一个潜在的靶点，同时专利效应记忆 T 细胞也会减少。
Potential Role of the Galectin-9/TIM-3 Axis in the Disparate Progression of SARS-CoV-2 in a Married Couple: A Case Report.
We report the disparate clinical progression of a couple infected by SARS-CoV-2 based on their immune checkpoint (IC) levels and immune cell distribution in blood from admission to exitus in patient 1 and from admission to discharge and recovery in patient 2. A detailed clinical follow-up accompanied by a longitudinal analysis of immune phenotypes and IC levels is shown. The continuous increase in the soluble IC ligand galectin-9 (Gal-9) and the increment in T-cell immunoglobulin and mucin domain-containing 3 (TIM-3) protein in T cells in patient 1 suggests an activation of the Gal-9/TIM-3 axis and, subsequently, a potential cell exhaustion in this patient that did not occur in patient 2. Our data indicate that the Gal-9/TIM-3 axis could be a potential target in this clinical setting, along with a patent effector memory T-cell reduction.
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