Mohammed Bashar Danlami, Basiru Aliyu, Grace Samuel
{"title":"尼日利亚凯比州门诊患者中推定的利福平耐药结核分枝杆菌病例的发生率。","authors":"Mohammed Bashar Danlami, Basiru Aliyu, Grace Samuel","doi":"10.21010/ajid.v15i1.6","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The present study determined the incidence of rifampicin resistance <i>M. tuberculosis</i> among outpatients at the General Hospital Yauri, Kebbi State, Nigeria.</p><p><strong>Materials and methods: </strong>The study is a cross-sectional study conducted from February 2018 to October 2019. Sociodemographic data were collected from hospital registration books. Rifampicin resistance <i>M. tuberculosis</i> was detected using GeneXpert Model GX-IV following manufacturers' instruction. Descriptive statistics and logistic regression were computed using SPSS version 20. The results were presented as odds ratios with associated 95% confidence intervals, and P-value at 0.05.</p><p><strong>Result: </strong>Of the 837 samples, 65.8% (551/837) were males, and 34.2% (286/837) females, 11.4% (95/837) HIV-seropositive. <i>M. tuberculosis</i> was detected in 15.5% (130/837), of which 116/130 (89.23%) were males and 14/130 (10.77%) females. <i>M. tuberculosis</i>-HIV coinfection was detected in 9.47% (9/95) of HIV positive. Rifampicin resistance was observed in 1.3% (11/837), 7.7% (10/130) in <i>M. tuberculosis</i> patients and 1.05% (1/94) in HIV seropositive. In logistic regression, the odds ratio for having a rifampicin-resistant <i>M. tuberculosis</i> was 0.49 (0.15-1.54) for > 30 years; taking <30 years as the reference value, 1.02 (1.00-1.03) for male; taking female as the reference value, and 0.78 (0.09-6.15) for HIV positive, taking negative as the reference value.</p><p><strong>Conclusion: </strong>This study reported the current incidence rate of rifampicin-resistant <i>M. tuberculosis</i> at the General Hospital Yelwa Yauri, Kebbi State, Nigeria, among presumptive TB patients. Patients diagnosed with rifampicin-resistant <i>M. tuberculosis</i> were predominantly male adults. Thus, frequent screening is vital for surveillance and reduces the risk of transmission and spread of <i>M. tuberculosis</i> infections.</p>","PeriodicalId":39108,"journal":{"name":"African Journal of Infectious Diseases","volume":"15 1","pages":"47-52"},"PeriodicalIF":0.0000,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047284/pdf/","citationCount":"4","resultStr":"{\"title\":\"INCIDENCE OF RIFAMPICIN-RESISTANCE PRESUMPTIVE <i>M. TUBERCULOSIS</i> CASES AMONG OUTPATIENTS IN KEBBI STATE, NIGERIA.\",\"authors\":\"Mohammed Bashar Danlami, Basiru Aliyu, Grace Samuel\",\"doi\":\"10.21010/ajid.v15i1.6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The present study determined the incidence of rifampicin resistance <i>M. tuberculosis</i> among outpatients at the General Hospital Yauri, Kebbi State, Nigeria.</p><p><strong>Materials and methods: </strong>The study is a cross-sectional study conducted from February 2018 to October 2019. Sociodemographic data were collected from hospital registration books. Rifampicin resistance <i>M. tuberculosis</i> was detected using GeneXpert Model GX-IV following manufacturers' instruction. Descriptive statistics and logistic regression were computed using SPSS version 20. The results were presented as odds ratios with associated 95% confidence intervals, and P-value at 0.05.</p><p><strong>Result: </strong>Of the 837 samples, 65.8% (551/837) were males, and 34.2% (286/837) females, 11.4% (95/837) HIV-seropositive. <i>M. tuberculosis</i> was detected in 15.5% (130/837), of which 116/130 (89.23%) were males and 14/130 (10.77%) females. <i>M. tuberculosis</i>-HIV coinfection was detected in 9.47% (9/95) of HIV positive. Rifampicin resistance was observed in 1.3% (11/837), 7.7% (10/130) in <i>M. tuberculosis</i> patients and 1.05% (1/94) in HIV seropositive. In logistic regression, the odds ratio for having a rifampicin-resistant <i>M. tuberculosis</i> was 0.49 (0.15-1.54) for > 30 years; taking <30 years as the reference value, 1.02 (1.00-1.03) for male; taking female as the reference value, and 0.78 (0.09-6.15) for HIV positive, taking negative as the reference value.</p><p><strong>Conclusion: </strong>This study reported the current incidence rate of rifampicin-resistant <i>M. tuberculosis</i> at the General Hospital Yelwa Yauri, Kebbi State, Nigeria, among presumptive TB patients. Patients diagnosed with rifampicin-resistant <i>M. tuberculosis</i> were predominantly male adults. Thus, frequent screening is vital for surveillance and reduces the risk of transmission and spread of <i>M. tuberculosis</i> infections.</p>\",\"PeriodicalId\":39108,\"journal\":{\"name\":\"African Journal of Infectious Diseases\",\"volume\":\"15 1\",\"pages\":\"47-52\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-12-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047284/pdf/\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"African Journal of Infectious Diseases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21010/ajid.v15i1.6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"African Journal of Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21010/ajid.v15i1.6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 4
摘要
背景:本研究确定了尼日利亚Kebbi州Yauri总医院门诊患者中耐利福平结核分枝杆菌的发病率。材料和方法:本研究是一项横断面研究,于2018年2月至2019年10月进行。社会人口统计数据从医院登记簿中收集。采用GeneXpert GX-IV型检测耐利福平结核分枝杆菌。描述性统计和逻辑回归计算使用SPSS version 20。结果以相关95%置信区间的比值比表示,p值为0.05。结果:837份样本中,男性65.8%(551/837),女性34.2% (286/837),hiv血清阳性11.4%(95/837)。结核分枝杆菌检出率为15.5%(130/837),其中男性116/130(89.23%),女性14/130(10.77%)。9.47%(9/95)的HIV阳性患者存在结核分枝杆菌合并感染。结核分枝杆菌耐药率分别为1.3%(11/837)、7.7%(10/130)和1.05%(1/94)。在logistic回归中,30年以上耐利福平结核分枝杆菌的优势比为0.49 (0.15-1.54);结论:本研究报告了目前尼日利亚Kebbi州Yelwa Yauri总医院推定结核病患者中耐利福平结核分枝杆菌的发病率。诊断为耐利福平结核分枝杆菌的患者以男性为主。因此,频繁的筛查对于监测和减少结核分枝杆菌感染传播和扩散的风险至关重要。
INCIDENCE OF RIFAMPICIN-RESISTANCE PRESUMPTIVE M. TUBERCULOSIS CASES AMONG OUTPATIENTS IN KEBBI STATE, NIGERIA.
Background: The present study determined the incidence of rifampicin resistance M. tuberculosis among outpatients at the General Hospital Yauri, Kebbi State, Nigeria.
Materials and methods: The study is a cross-sectional study conducted from February 2018 to October 2019. Sociodemographic data were collected from hospital registration books. Rifampicin resistance M. tuberculosis was detected using GeneXpert Model GX-IV following manufacturers' instruction. Descriptive statistics and logistic regression were computed using SPSS version 20. The results were presented as odds ratios with associated 95% confidence intervals, and P-value at 0.05.
Result: Of the 837 samples, 65.8% (551/837) were males, and 34.2% (286/837) females, 11.4% (95/837) HIV-seropositive. M. tuberculosis was detected in 15.5% (130/837), of which 116/130 (89.23%) were males and 14/130 (10.77%) females. M. tuberculosis-HIV coinfection was detected in 9.47% (9/95) of HIV positive. Rifampicin resistance was observed in 1.3% (11/837), 7.7% (10/130) in M. tuberculosis patients and 1.05% (1/94) in HIV seropositive. In logistic regression, the odds ratio for having a rifampicin-resistant M. tuberculosis was 0.49 (0.15-1.54) for > 30 years; taking <30 years as the reference value, 1.02 (1.00-1.03) for male; taking female as the reference value, and 0.78 (0.09-6.15) for HIV positive, taking negative as the reference value.
Conclusion: This study reported the current incidence rate of rifampicin-resistant M. tuberculosis at the General Hospital Yelwa Yauri, Kebbi State, Nigeria, among presumptive TB patients. Patients diagnosed with rifampicin-resistant M. tuberculosis were predominantly male adults. Thus, frequent screening is vital for surveillance and reduces the risk of transmission and spread of M. tuberculosis infections.