免疫记忆在控制感染中的阴阳作用:超越自我防御机制。

IF 4.3 4区 医学 Q2 IMMUNOLOGY
International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2021-04-19 DOI:10.1080/08830185.2021.1912037
Roshan Kumar Roy, Rakhi Yadav, Aklank Jain, Vishwas Tripathi, Manju Jain, Sandhya Singh, Hridayesh Prakash
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引用次数: 1

摘要

免疫记忆对宿主免疫至关重要,并决定个体对先前遇到的感染作出指数级反应。已知T细胞和B细胞记忆都通过其中枢和效应记忆臂协调免疫记忆,有助于延长宿主的免疫/防御机制。中枢记忆有助于维持对特定感染的长期免疫,而效应记忆则有助于控制局部/季节性感染。除此之外,长寿命浆细胞的产生对于产生中和抗体至关重要,它可以增强回忆和B细胞记忆以控制再次感染。鉴于此,扩大记忆反应是疫苗接种预期结果的主要目标之一。本文就记忆细胞在各种感染中的作用、记忆细胞发育、维持的分子途径、表观遗传调控和负调控等方面进行综述。我们还强调了T细胞和B细胞记忆反应在预防感染的疫苗接种方法中的重要性,这一点迄今尚未得到充分探讨。[方框:见文本]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Yin and yang of immunological memory in controlling infections: Overriding self defence mechanisms.

Immunological memory is critical for host immunity and decisive for individual to respond exponentially to previously encountered infection. Both T and B cell memory are known to orchestrate immunological memory with their central and effector memory arms contributing in prolonged immunity/defence mechanisms of host. While central memory helps in maintaining prolonged immunity for a particular infection, effector memory helps in keeping local/seasonal infection in control. In addition to this, generation of long-lived plasma cells is pivotal for generating neutralizing antibodies which can enhance recall and B cell memory to control re-infection. In view of this, scaling up memory response is one of the major objectives for the expected outcome of vaccination. In this line, this review deals with the significance of memory cells, molecular pathways of their development, maintenance, epigenetic regulation and negative regulation in various infections. We have also highlighted the significance of both T and B cell memory responses in the vaccination approaches against range of infections which is not fully explored so far.[Box: see text].

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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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