回盲部MiNEN合并非小细胞肺癌1例报告及文献复习。

IF 0.6 Q4 ONCOLOGY
Case Reports in Oncological Medicine Pub Date : 2021-03-31 eCollection Date: 2021-01-01 DOI:10.1155/2021/8896254
Santiago Teran, Maria Camara Jurado, Juan Antonio Nuñez Sobrino
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引用次数: 0

摘要

混合性神经内分泌非神经内分泌肿瘤(MiNENs)是由两种不同组织学成分组成的罕见肿瘤,其中一种来源于神经内分泌。鉴于该病的诊断不足和由此导致的低患病率,目前尚无明确的诊断和治疗指南,治疗方案通常与最积极的治疗方案相似。另一方面,多发原发肿瘤(mpt)也是罕见的肿瘤实体,通常会给治疗选择带来挑战,因为应该使用包括原发和同步/异时恶性肿瘤的治疗方案。在这里,我们讨论了一个伴有同步鳞状非小细胞肺癌(SQ-NSCLC)的回盲部MiNEN患者具有挑战性的诊断和治疗管理。患者表现出肠梗阻症状,因此他接受了回盲部MiNEN的紧急切除术。最初的CT扫描显示一个额外的肺肿块,后来在支气管镜活检分析后确定为SQ-NSCLC。鉴于肝转移进展迅速,开始姑息性铂基化疗,对MiNEN的局部和转移性病变有足够的反应,但提示铂耐药和肺肿瘤进展。开始了针对SQ-NSCLC的派姆单抗二线治疗;然而,在出现免疫介导的毒性后,它被停止了。开始了卡铂/吉西他滨三线化疗方案,但中枢神经系统(CNS)进展,患者在初步诊断后11个月死亡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A Patient with an Ileocecal MiNEN and a Synchronous Squamous Non-Small-Cell Lung Cancer: Case Report and Review of the Literature.

A Patient with an Ileocecal MiNEN and a Synchronous Squamous Non-Small-Cell Lung Cancer: Case Report and Review of the Literature.

A Patient with an Ileocecal MiNEN and a Synchronous Squamous Non-Small-Cell Lung Cancer: Case Report and Review of the Literature.

Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) are rare tumors composed of two different histological components, one of which is of a neuroendocrine origin. Given its suggested underdiagnosis and consequent low prevalence, no clear diagnostic and treatment guidelines are available, and treatment usually follows regimens similar to that of the most aggressive component. On the other hand, multiple primary tumors (MPTs) are also rare neoplastic entities that usually confer a challenge regarding treatment options, for a regimen that comprises both the primary and the synchronous/metachronous malignancy should be used. Here, we discuss the challenging diagnostic and therapeutic management of a patient with an ileocecal MiNEN that presented along with a synchronous squamous non-small-cell lung cancer (SQ-NSCLC). The patient presented with intestinal obstruction symptoms for which he underwent an emergency resection of the ileocecal MiNEN. An initial CT scan showed an additional lung mass later identified as an SQ-NSCLC after bronchoscopy biopsy analysis. Given the rapid hepatic metastatic progression, palliative platinum-based chemotherapy was initiated, with an adequate response of the local and metastatic lesions of the MiNEN, but suggested platinum resistance and progression of the pulmonary neoplasm. Second-line treatment with pembrolizumab directed for the SQ-NSCLC was initiated; however, it was stopped after immune-mediated toxicities developed. A third-line chemotherapy scheme with carboplatin/gemcitabine was initiated, but central nervous system (CNS) progression developed, with the patient dying 11 months after initial diagnosis.

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来源期刊
自引率
0.00%
发文量
11
审稿时长
16 weeks
期刊介绍: Case Reports in Oncological Medicine is a peer-reviewed, Open Access journal that publishes case reports and case series related to breast cancer, lung cancer, gastrointestinal cancer, skin cancer, head and neck cancer, paediatric oncology, neurooncology as well as genitourinary cancer.
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