Iris Cristina Maia Oliveira, Auriana Serra Vasconcelos Mallmann, Francisco Adelvane de Paula Rodrigues, Laura Maria Teodorio Vidal, Iardja Stéfane Lopes Sales, Gabriel Carvalho Rodrigues, Natalia Ferreira de Oliveira, Raquell de Castro Chaves, Victor Celso Cavalcanti Capibaribe, Alyne Mara Rodrigues de Carvalho, Marta Maria de França Fonteles, Stanley Juan Chavez Gutierrez, José Maria Barbosa-Filho, Francisca Cléa Florenço de Sousa
{"title":"利帕林1在皮质酮诱导的雌性小鼠抑郁模型中的神经保护和抗氧化作用。","authors":"Iris Cristina Maia Oliveira, Auriana Serra Vasconcelos Mallmann, Francisco Adelvane de Paula Rodrigues, Laura Maria Teodorio Vidal, Iardja Stéfane Lopes Sales, Gabriel Carvalho Rodrigues, Natalia Ferreira de Oliveira, Raquell de Castro Chaves, Victor Celso Cavalcanti Capibaribe, Alyne Mara Rodrigues de Carvalho, Marta Maria de França Fonteles, Stanley Juan Chavez Gutierrez, José Maria Barbosa-Filho, Francisca Cléa Florenço de Sousa","doi":"10.1159/000515929","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Depression is a common, chronic, and often recurrent serious mood disorder. Conventional antidepressants present limitations that stimulate the search for new drugs. Antioxidant and neuroprotective substances are potential antidepressant agents. In this context, riparin I (RIP I) has presented promising results, emerging as a potential source of a new therapeutic drug. In this study, the antidepressant effect of RIP I was evaluated in an animal model of depression induced by corticosterone (CORT). The involvement of neuroprotective and antioxidant mechanisms in the generation of this effect was also assessed.</p><p><strong>Methods: </strong>Female mice were submitted to CORT for 21 days and treated with RIP I in the last 7 days. Behavioral and neurochemical analyses were performed.</p><p><strong>Results: </strong>The administration of RIP I reversed the depressive and psychotic-like behavior, as well as the cognitive impairment caused by CORT, in addition to regulating oxidative stress parameters and BDNF levels in depression-related brain areas.</p><p><strong>Conclusion: </strong>These findings suggest that RIP I can be a strong candidate for drugs in the treatment of depression.</p>","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000515929","citationCount":"6","resultStr":"{\"title\":\"Neuroprotective and Antioxidant Effects of Riparin I in a Model of Depression Induced by Corticosterone in Female Mice.\",\"authors\":\"Iris Cristina Maia Oliveira, Auriana Serra Vasconcelos Mallmann, Francisco Adelvane de Paula Rodrigues, Laura Maria Teodorio Vidal, Iardja Stéfane Lopes Sales, Gabriel Carvalho Rodrigues, Natalia Ferreira de Oliveira, Raquell de Castro Chaves, Victor Celso Cavalcanti Capibaribe, Alyne Mara Rodrigues de Carvalho, Marta Maria de França Fonteles, Stanley Juan Chavez Gutierrez, José Maria Barbosa-Filho, Francisca Cléa Florenço de Sousa\",\"doi\":\"10.1159/000515929\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Depression is a common, chronic, and often recurrent serious mood disorder. 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Behavioral and neurochemical analyses were performed.</p><p><strong>Results: </strong>The administration of RIP I reversed the depressive and psychotic-like behavior, as well as the cognitive impairment caused by CORT, in addition to regulating oxidative stress parameters and BDNF levels in depression-related brain areas.</p><p><strong>Conclusion: </strong>These findings suggest that RIP I can be a strong candidate for drugs in the treatment of depression.</p>\",\"PeriodicalId\":19239,\"journal\":{\"name\":\"Neuropsychobiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1159/000515929\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuropsychobiology\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://doi.org/10.1159/000515929\",\"RegionNum\":4,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/4/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuropsychobiology","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1159/000515929","RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/4/29 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Neuroprotective and Antioxidant Effects of Riparin I in a Model of Depression Induced by Corticosterone in Female Mice.
Background: Depression is a common, chronic, and often recurrent serious mood disorder. Conventional antidepressants present limitations that stimulate the search for new drugs. Antioxidant and neuroprotective substances are potential antidepressant agents. In this context, riparin I (RIP I) has presented promising results, emerging as a potential source of a new therapeutic drug. In this study, the antidepressant effect of RIP I was evaluated in an animal model of depression induced by corticosterone (CORT). The involvement of neuroprotective and antioxidant mechanisms in the generation of this effect was also assessed.
Methods: Female mice were submitted to CORT for 21 days and treated with RIP I in the last 7 days. Behavioral and neurochemical analyses were performed.
Results: The administration of RIP I reversed the depressive and psychotic-like behavior, as well as the cognitive impairment caused by CORT, in addition to regulating oxidative stress parameters and BDNF levels in depression-related brain areas.
Conclusion: These findings suggest that RIP I can be a strong candidate for drugs in the treatment of depression.
期刊介绍：
The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.
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