乳腺肿瘤微环境中癌症相关成纤维细胞的研究

IF 3 4区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Mammary Gland Biology and Neoplasia Pub Date : 2021-06-01 Epub Date: 2021-01-04 DOI:10.1007/s10911-020-09475-y

María Belén Giorello, Francisco Raúl Borzone, Vivian Labovsky, Flavia Valeria Piccioni, Norma Alejandra Chasseing

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引用次数: 17

摘要

多年的研究揭示了乳腺肿瘤上皮细胞受基质微环境影响的理论。本文旨在讨论癌症相关成纤维细胞(CAFs)的表型和功能特征及其在肿瘤进化中的作用，以及它们对抗癌治疗的潜在意义。在这篇文章中，我们回顾了cas在乳腺癌的发生、生长、侵袭和转移中发挥的重要作用，并在乳腺癌的临床诊断、治疗和预后中发挥生物标志物的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cancer-Associated Fibroblasts in the Breast Tumor Microenvironment.

Years of investigation have shed light on a theory in which breast tumor epithelial cells are under the effect of the stromal microenvironment. This review aims to discuss recent findings concerning the phenotypic and functional characteristics of cancer associated fibroblasts (CAFs) and their involvement in tumor evolution, as well as their potential implications for anti-cancer therapy. In this manuscript, we reviewed that CAFs play a fundamental role in initiation, growth, invasion, and metastasis of breast cancer, and also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of this disease.

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来源期刊

Journal of Mammary Gland Biology and Neoplasia 医学-内分泌学与代谢

CiteScore

5.30

自引率

4.00%

发文量

期刊介绍： Journal of Mammary Gland Biology and Neoplasia is the leading Journal in the field of mammary gland biology that provides researchers within and outside the field of mammary gland biology with an integrated source of information pertaining to the development, function, and pathology of the mammary gland and its function. Commencing in 2015, the Journal will begin receiving and publishing a combination of reviews and original, peer-reviewed research. The Journal covers all topics related to the field of mammary gland biology, including mammary development, breast cancer biology, lactation, and milk composition and quality. The environmental, endocrine, nutritional, and molecular factors regulating these processes is covered, including from a comparative biology perspective.