一些膳食对类风湿关节炎发病过程中肠道微生物群的治疗作用(Amavata)综述。

Ayu Pub Date : 2019-07-01 Epub Date: 2020-08-08 DOI:10.4103/ayu.AYU_192_19
Y S Aswathy, P V Anandaraman
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引用次数: 3

摘要

背景:Amavata是一种慢性免疫炎性全身性疾病,由Ama的形成及其与Kaphasthana(关节)的Vata相关引起,可与类风湿关节炎(RA)模拟。已发表的证据表明,Amavata所指示的治疗对RA有效。RA中炎症状态的增加提示涉及肠道微生物群(GM)的肠道生态失调。目的:本研究的目的是根据Amavata所提到的Pathya(饮食建议)分析饮食对RA患者GM的影响。材料与方法:对《阿玛瓦塔》中的《巴瓦拉卡沙》、《Madhava尼达那》和《Sharangadhara尼达那》等Laghutrayis,《巴瓦拉卡沙尼达那》和《尼伽拉那那》等梵语词汇,以及《阿玛瓦塔之路》等不同的数据库进行了检索。检索PubMed、Scopus、DHARA、Google Scholar、Science Direct等数据库,对马克、大麦、大蒜、生姜、鸡腿叶、牛尿和酪乳中非营养性生物活性成分在RA治疗中的作用进行综述。发现Pathya通过Bowman - Birk抑制剂和多酚类化合物降低或抑制炎症标志物,如白细胞介素- 6 (IL - 6)、17和白蛋白,从而影响GM。其中,Takra已经被证明是一种益生菌。Gomutra增强B淋巴细胞和T淋巴细胞,IL - 1和IL - 2,增强免疫系统。结论:Amavata中提到的Pathya Ahara与RA患者GM有直接关系。尽管药理作用已被临床证明/实践,但本综述为其科学基础提供了证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapeutic influence of some dietary articles on gut microbiota in the pathogenesis of rheumatoid arthritis (Amavata) - A review.

Background: Amavata is a chronic immune‑inflammatory systemic disorder caused by the formation of Ama and its association with Vata at Kaphasthana (joints) and can be simulated with rheumatoid arthritis (RA). Published evidences show that treatment indicated in Amavata is effective in RA. Increased inflammatory status in RA is suggestive of gut dysbiosis involving gut microbiota (GM).

Aim: The aim of the present study was to analyze the influence of diet on GM of RA patients based on Pathya (dietary advice) mentioned for Amavata.

Materials and methods: Laghutrayis such as Bhavaprakasha Samhita, Madhava Nidana and Sharangadhara Samhita, Bhaishajya Ratnavali and Nighantus (Sanskrit glossary) such as Raja Nighantu, Bhavaprakasha Nighantu and Yogaratnakara, Ashtanga Hridaya also different databases were reviewed for Pathya of Amavata. Different databases such as PubMed, Scopus, DHARA, Google Scholar, Science Direct were searched with research papers establishing the role of nonnutritive bioactive components in horse gram, barley, garlic, ginger, drumstick leaves, cow urine and buttermilk in the management of RA were also reviewed. It was found that Pathya influences on the GM by lowering or inhibiting inflammatory markers such as interleukin‑6 (IL‑6), 17 and leukotrines through Bowman‑Birk inhibitors and polyphenolic compounds. Among them, Takra is already a proven probiotic. Gomutra augments B and T lymphocytes, IL‑1 and IL‑2, strengthening the immune system.

Conclusion: It was concluded that Pathya Ahara mentioned for Amavata have a direct link with GM of RA patients. Even though the pharmacological actions have been clinically proven/practised, this review creates evidence for its scientific basis.

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