黑草醇提物对中重度牙龈炎临床参数的影响评价:一项裂口临床研究。

Ayu Pub Date : 2019-07-01 Epub Date: 2020-08-08 DOI:10.4103/ayu.AYU_68_18
Vibha Singh, Abhaya Gupta, Umesh Pratap Verma, Tripti Mishra, Mahesh Pal
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引用次数: 9

摘要

牙龈炎是一种相对无害、可逆性的牙龈炎症。如果不及时治疗,它可能会发展到牙齿的深层牙周组织,从而导致牙齿的活动和脱落。令人信服的文献表明,局部抗菌和抗炎剂作为治疗牙周病的辅助手段,可用于洗牙和牙根刨(金标准)。各种草药,如印楝(Azadirachta indica A. Juss),巴巴拉(Vachellia nilotica (L.))。P.J.H. Hurter & Mabb)和姜黄(Curcuma longa L.)自古以来就被用于治疗牙龈炎。黑草(Nigella sativa L., Kalonji)就是其中一种以其显著的抗炎、抗氧化和抗菌特性而闻名的草药,因此在本研究中被利用。目的:探讨不同乙醇溶液对中重度牙龈炎患者的临床疗效。材料和方法:这是一项分口临床研究,24例年龄在25-45岁的中重度牙龈炎患者。将入选个体分为I1组、II1组和III1组(除垢和根规划即对照组)和I2组、II2组和III2组(实验组)。实验组按溶液1(1:3)、溶液2(1:1)、溶液3(3:1)三种剂量连续给予3 d。记录所有个体在基线、14天和28天的临床参数牙龈指数(GI)和菌斑指数(PI)。本研究采用方差分析进行统计分析。结果:组间比较,I1与i2在距基线14天、28天有统计学差异,II1与II2仅在距基线28天有统计学差异,III1与III2在距基线各时间间隔均无统计学差异。组内比较,各组从基线至28 d的GI下降均有统计学意义,但试验组中以ii2组效果最好(P < 0.001;F值153.75)。在PI方面,不同组间比较,I1& I2、II1& II2、III1& III2组间比较,从基线到第14、28天,差异均有统计学意义。组内比较,I1、II1、II1 3个对照组PI均有统计学意义降低,实验组间仅III2组PI有统计学意义降低(P < 0.001, F值30.40)。结论:芥蓝乙醇提取物对中重度牙龈炎有较好的治疗作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

An evaluation of the efficacy of ethanolic extract of <i>Nigella sativa</i> L. (<i>Kalonji</i>) on the clinical parameters of moderate‑to‑severe gingivitis: A split‑mouth clinical study.

An evaluation of the efficacy of ethanolic extract of <i>Nigella sativa</i> L. (<i>Kalonji</i>) on the clinical parameters of moderate‑to‑severe gingivitis: A split‑mouth clinical study.

An evaluation of the efficacy of ethanolic extract of <i>Nigella sativa</i> L. (<i>Kalonji</i>) on the clinical parameters of moderate‑to‑severe gingivitis: A split‑mouth clinical study.

An evaluation of the efficacy of ethanolic extract of Nigella sativa L. (Kalonji) on the clinical parameters of moderate‑to‑severe gingivitis: A split‑mouth clinical study.

Introduction: Gingivitis is a relatively innocuous and reversible inflammation of gingiva. If left untreated, it might progress involving the deeper supporting periodontal tissues of the tooth with consequent mobility and tooth loss. Compelling literature has suggested the role of local antibacterial and anti‑inflammatory agents as an adjunct to scaling and root planing (gold standard) for treating periodontal diseases. Various herbs such as Nimba (Azadirachta indica A. Juss), Babbula (Vachellia nilotica (L.) P.J.H. Hurter & Mabb.) and turmeric (Curcuma longa L.) have been used for gingivitis since ancient times. Nigella sativa L. (Kalonji) is one such herb known for its remarkable anti‑inflammatory, antioxidant and antimicrobial properties and thus has been utilized in the present study.

Aim: The aim of the study was to explore the clinical efficacy of different ethanolic solutions of N. sativa in moderate‑to‑severe gingivitis patients.

Materials and methods: It is a split‑mouth clinical study with 24 patients of moderate‑to‑severe gingivitis from the age group of 25-45 years. Recruited individuals were divided in to group I1, group II1 and group III1 (scaling and root planning i.e., control) and group I2, group II2 and group III2 (experimental). Three doses of solution 1 (1:3), solution 2 (1:1) and solution 3 (3:1) were administered to the experimental groups for 3 consecutive days. The clinical parameters, i.e., gingival index (GI) and plaque index (PI) were recorded at baseline, 14 days and 28 days in all the individuals. ANOVA test was used in the study for statistical analysis.

Results: Intergroup comparison in terms of GI showed statistically significant difference at 14th and 28th day from baseline between I1 &I2, at only 28th day between II1 & II2 and insignificant difference between III1 & III2 at all time intervals from baseline. On intragroup comparison, statistically significant reduction in GI in all groups from baseline till 28 days was found, but among experimental groups best result was seen in group III2 (P < 0.001; F value 153.75). As far as PI is concerned, intergroup comparison between different groups displayed statistically significant difference from baseline to 14th and 28th day between all groups i.e I1& I2, II1& II2 and III1& III2. On intragroup comparison, statistically significant reduction in PI in all control groups i.e I1, II1 & III1 was found, but among experimental groups only group III2 provided statistically significant reduction (P < 0.001, F value 30.40).

Conclusion: The results of this study indicate that, the ethanolic extract of N. sativa is effective in the treatment of moderate to severe gingivitis.

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