{"title":"对局部药物的过敏性接触性皮炎:重新审视。","authors":"Supitchaya Thaiwat, Taksaorn PhayangkheUbol","doi":"10.12932/AP-180820-0944","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Allergic reaction to topical drugs varies depending on use and availability of topical drugs and self-medication.</p><p><strong>Objective: </strong>We aimed to determine the incidence of contact dermatitis to topical medicaments among patients referred for patch testing.</p><p><strong>Methods: </strong>All patients with suspected allergic contact dermatitis were patch tested with standard and medicament series. The characterization was performed according to the MOAHLFA index.</p><p><strong>Results: </strong>59/215 (27.4%) patients had positive reactions to at least 1 medicament but only 13/59 (22.0%) had a relevant history. The 3 most common positive medicaments were framycetin 23/215 (10.7%), miconazole 22/215 (10.2%), and econazole 17/215 (7.9%). Among those positive to medicament, face was the most common location 22/59 (37.3%). 39/215 (18.1%) had more than 2 co-positive standard allergens and showed significant higher rate of topical medicament sensitization. The contributing factors of medicament allergy were the history of suspected allergens in personal care products (OR = 2.09, P = 0.038), topical drugs (OR = 2.93, P = 0.002), topical treatment (OR = 2.47, P = 0.011), and history of drug allergy (OR = 1.78, P = 0.023).</p><p><strong>Conclusions: </strong>The study showed a high rate of medicament sensitization especially antibiotic and antifungal drugs. The incidence of positive medicament patch test result was associated with facial dermatitis. Polysensitization and history of previous exposure, either as treatment or overusing of drugs, significantly associated with medicament positive patients. This study supports the inclusion of medicaments within the standard series of patch test.</p>","PeriodicalId":8552,"journal":{"name":"Asian Pacific journal of allergy and immunology","volume":" ","pages":"318-324"},"PeriodicalIF":2.3000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Allergic contact dermatitis to topical medicaments: Revisited.\",\"authors\":\"Supitchaya Thaiwat, Taksaorn PhayangkheUbol\",\"doi\":\"10.12932/AP-180820-0944\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Allergic reaction to topical drugs varies depending on use and availability of topical drugs and self-medication.</p><p><strong>Objective: </strong>We aimed to determine the incidence of contact dermatitis to topical medicaments among patients referred for patch testing.</p><p><strong>Methods: </strong>All patients with suspected allergic contact dermatitis were patch tested with standard and medicament series. The characterization was performed according to the MOAHLFA index.</p><p><strong>Results: </strong>59/215 (27.4%) patients had positive reactions to at least 1 medicament but only 13/59 (22.0%) had a relevant history. The 3 most common positive medicaments were framycetin 23/215 (10.7%), miconazole 22/215 (10.2%), and econazole 17/215 (7.9%). Among those positive to medicament, face was the most common location 22/59 (37.3%). 39/215 (18.1%) had more than 2 co-positive standard allergens and showed significant higher rate of topical medicament sensitization. The contributing factors of medicament allergy were the history of suspected allergens in personal care products (OR = 2.09, P = 0.038), topical drugs (OR = 2.93, P = 0.002), topical treatment (OR = 2.47, P = 0.011), and history of drug allergy (OR = 1.78, P = 0.023).</p><p><strong>Conclusions: </strong>The study showed a high rate of medicament sensitization especially antibiotic and antifungal drugs. The incidence of positive medicament patch test result was associated with facial dermatitis. Polysensitization and history of previous exposure, either as treatment or overusing of drugs, significantly associated with medicament positive patients. 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引用次数: 3
摘要
背景:对外用药物的过敏反应取决于外用药物的使用和可得性以及自我用药。目的:我们的目的是确定接触性皮炎的发生率,局部药物在患者转到贴片试验。方法:对所有疑似变态反应性接触性皮炎患者进行标准和药物系列的斑贴试验。根据MOAHLFA指数进行表征。结果:215例患者中有59例(27.4%)对至少1种药物有阳性反应,仅有13例(22.0%)有相关史。最常见的3种阳性药物分别是弗拉西丁23/215(10.7%)、咪康唑22/215(10.2%)和康康唑17/215(7.9%)。在药物阳性的患者中,面部是最常见的部位,22/59(37.3%)。39/215(18.1%)患者2个以上标准过敏原阳性,外用药物致敏率显著高于其他患者。药物过敏的影响因素为个人护理用品疑似过敏原史(OR = 2.09, P = 0.038)、外用药物史(OR = 2.93, P = 0.002)、外用治疗史(OR = 2.47, P = 0.011)、药物过敏史(OR = 1.78, P = 0.023)。结论:本研究显示药物致敏率高,尤其是抗生素和抗真菌药物。药物斑贴试验阳性的发生率与面部皮炎相关。多致敏和既往用药史,无论是作为治疗还是过度用药,均与药物阳性患者显著相关。本研究支持将药物纳入标准系列的斑贴试验。
Allergic contact dermatitis to topical medicaments: Revisited.
Background: Allergic reaction to topical drugs varies depending on use and availability of topical drugs and self-medication.
Objective: We aimed to determine the incidence of contact dermatitis to topical medicaments among patients referred for patch testing.
Methods: All patients with suspected allergic contact dermatitis were patch tested with standard and medicament series. The characterization was performed according to the MOAHLFA index.
Results: 59/215 (27.4%) patients had positive reactions to at least 1 medicament but only 13/59 (22.0%) had a relevant history. The 3 most common positive medicaments were framycetin 23/215 (10.7%), miconazole 22/215 (10.2%), and econazole 17/215 (7.9%). Among those positive to medicament, face was the most common location 22/59 (37.3%). 39/215 (18.1%) had more than 2 co-positive standard allergens and showed significant higher rate of topical medicament sensitization. The contributing factors of medicament allergy were the history of suspected allergens in personal care products (OR = 2.09, P = 0.038), topical drugs (OR = 2.93, P = 0.002), topical treatment (OR = 2.47, P = 0.011), and history of drug allergy (OR = 1.78, P = 0.023).
Conclusions: The study showed a high rate of medicament sensitization especially antibiotic and antifungal drugs. The incidence of positive medicament patch test result was associated with facial dermatitis. Polysensitization and history of previous exposure, either as treatment or overusing of drugs, significantly associated with medicament positive patients. This study supports the inclusion of medicaments within the standard series of patch test.
期刊介绍:
The Asian Pacific Journal of Allergy and Immunology (APJAI) is an online open access journal with the recent impact factor (2018) 1.747
APJAI published 4 times per annum (March, June, September, December). Four issues constitute one volume.
APJAI publishes original research articles of basic science, clinical science and reviews on various aspects of allergy and immunology. This journal is an official journal of and published by the Allergy, Asthma and Immunology Association, Thailand.
The scopes include mechanism, pathogenesis, host-pathogen interaction, host-environment interaction, allergic diseases, immune-mediated diseases, epidemiology, diagnosis, treatment and prevention, immunotherapy, and vaccine. All papers are published in English and are refereed to international standards.