[11C]蛋氨酸和[11C]PBR28作为鉴别转移性肿瘤复发或放射性坏死的PET显像示踪剂。

IF 2.2 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS
Thuy T Tran, Jean-Dominique Gallezot, Lucia B Jilaveanu, Christopher Zito, Gabriela Turcu, Keunpoong Lim, Nabeel Nabulsi, Henry Huang, Anita Huttner, Harriet M Kluger, Veronica L Chiang, Richard Carson
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引用次数: 11

摘要

目的:随着立体定向放射外科(SRS)和免疫治疗越来越多地用于治疗脑转移瘤,放射性坏死(RN)的发病率也随之上升。区分肿瘤再生(TR)和肿瘤再生(RN)在治疗中是至关重要的,但很难用MRI来评估。我们假设,由于代谢增加和高氨基酸摄取,肿瘤蛋氨酸水平会升高,而RN会增加炎症,其特征是转运蛋白(PBR-TSPO)上调,这可以用特定的PET示踪剂量化。我们进行了一项可行性研究,在5例既往接受srs治疗的7例脑转移瘤中,使用PET前瞻性评估[11C]蛋氨酸和[11C]PBR28,以区分TR和RN。结果:双示踪剂序贯成像耐受良好。[11C]蛋氨酸在7/7的病变中准确检测病理证实的TR,而[11C]PBR28仅在3/7的病变中准确。肿瘤PBR-TSPO在黑色素瘤和肺癌细胞中的表达均升高,导致[11C]PBR28-PET缺乏特异性。结论:序贯使用PET示踪剂是安全有效的。[11C]蛋氨酸是可靠的TR标记物,而[11C]PBR28不是可靠的RN标记物。需要研究确定放射后炎症的原因,并确定RN的特异性标志物,以提高诊断成像。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

[<sup>11</sup>C]Methionine and [<sup>11</sup>C]PBR28 as PET Imaging Tracers to Differentiate Metastatic Tumor Recurrence or Radiation Necrosis.

[<sup>11</sup>C]Methionine and [<sup>11</sup>C]PBR28 as PET Imaging Tracers to Differentiate Metastatic Tumor Recurrence or Radiation Necrosis.

[<sup>11</sup>C]Methionine and [<sup>11</sup>C]PBR28 as PET Imaging Tracers to Differentiate Metastatic Tumor Recurrence or Radiation Necrosis.

[11C]Methionine and [11C]PBR28 as PET Imaging Tracers to Differentiate Metastatic Tumor Recurrence or Radiation Necrosis.

Purpose: As stereotactic radiosurgery (SRS) and immunotherapy are increasingly used to treat brain metastases, incidence of radiation necrosis (RN) is consequently rising. Differentiating tumor regrowth (TR) from RN is vital in management but difficult to assess using MRI. We hypothesized that tumor methionine levels would be elevated given increased metabolism and high amino acid uptake, whereas RN would increase inflammation marked by upregulated translocator protein (PBR-TSPO), which can be quantified with specific PET tracers.

Procedures: We performed a feasibility study to prospectively evaluate [11C]methionine and [11C]PBR28 using PET in 5 patients with 7 previously SRS-treated brain metastases demonstrating regrowth to differentiate TR from RN.

Results: Sequential imaging with dual tracers was well-tolerated. [11C]methionine was accurate for detecting pathologically confirmed TR in 7/7 lesions, whereas [11C]PBR28 was only accurate in 3/7 lesions. Tumor PBR-TSPO expression was elevated in both melanoma and lung cancer cells, contributing to lack of specificity of [11C]PBR28-PET.

Conclusion: Sequential use of PET tracers is safe and effective. [11C]Methionine was a reliable TR marker, but [11C]PBR28 was not a reliable marker of RN. Studies are needed to determine the causes of post-radiation inflammation and identify specific markers of RN to improve diagnostic imaging.

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来源期刊
Molecular Imaging
Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology
自引率
3.60%
发文量
21
期刊介绍: Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.
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