Eleazar E Reward, Anthony C Ike, Sophia O Muo, Busola F Soga-Oke, Emmanuel M Mbaawuaga
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The pooled estimates were calculated using the random effects model. Heterogeneity was assessed using Cochran's Q and I 2 statistic. Univariate and multivariate meta-regressions were done to predict sources of between-study heterogeneity. Overall, the pooled prevalence of TB/HIV coinfection was 25.8%. The highest coinfection prevalence of 34.3% was recorded among the North Central States of Nigeria, while the least prevalence of 19.3% was recorded among the Southeastern states of Nigeria. There was a paucity of published articles from the Northeastern states of Nigeria. There was a significant heterogeneity between studies (I2 > 90%, p < 0.001), but meta-regression analysis only explained < 10% of it. This study has shown that the prevalence of TB/HIV coinfection remains significantly high in Nigeria. Constant surveillance should be rigorously implemented with special attention given to the Northeast due to the ongoing crises that are compounding the problem.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Coinfection of Tuberculosis and HIV in Nigeria: A Systematic Review and Meta-analysis.\",\"authors\":\"Eleazar E Reward, Anthony C Ike, Sophia O Muo, Busola F Soga-Oke, Emmanuel M Mbaawuaga\",\"doi\":\"10.24875/AIDSRev.20000068\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Tuberculosis (TB) and HIV/AIDS are major public health issues globally. The burden of these diseases is particularly significant in Nigeria due to the high TB and HIV/AIDS prevalence. This meta-analysis for the 1st time addressed the TB/HIV coinfection prevalence in Nigeria at the regional level. A total of 58 relevant publications comprising 80 studies (n = 44,508) were obtained from PUBMED, ScienceDirect, African Journals Online, and Cochrane Library databases using carefully constructed keywords combinations. The PRISMA guideline was followed for this meta-analysis. Two independent reviewers conducted the publication screening, data extraction and methodological quality appraisal with a third reviewer serving as arbitrator. The pooled estimates were calculated using the random effects model. Heterogeneity was assessed using Cochran's Q and I 2 statistic. Univariate and multivariate meta-regressions were done to predict sources of between-study heterogeneity. Overall, the pooled prevalence of TB/HIV coinfection was 25.8%. The highest coinfection prevalence of 34.3% was recorded among the North Central States of Nigeria, while the least prevalence of 19.3% was recorded among the Southeastern states of Nigeria. There was a paucity of published articles from the Northeastern states of Nigeria. There was a significant heterogeneity between studies (I2 > 90%, p < 0.001), but meta-regression analysis only explained < 10% of it. This study has shown that the prevalence of TB/HIV coinfection remains significantly high in Nigeria. Constant surveillance should be rigorously implemented with special attention given to the Northeast due to the ongoing crises that are compounding the problem.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2020-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.24875/AIDSRev.20000068\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.24875/AIDSRev.20000068","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Coinfection of Tuberculosis and HIV in Nigeria: A Systematic Review and Meta-analysis.
Tuberculosis (TB) and HIV/AIDS are major public health issues globally. The burden of these diseases is particularly significant in Nigeria due to the high TB and HIV/AIDS prevalence. This meta-analysis for the 1st time addressed the TB/HIV coinfection prevalence in Nigeria at the regional level. A total of 58 relevant publications comprising 80 studies (n = 44,508) were obtained from PUBMED, ScienceDirect, African Journals Online, and Cochrane Library databases using carefully constructed keywords combinations. The PRISMA guideline was followed for this meta-analysis. Two independent reviewers conducted the publication screening, data extraction and methodological quality appraisal with a third reviewer serving as arbitrator. The pooled estimates were calculated using the random effects model. Heterogeneity was assessed using Cochran's Q and I 2 statistic. Univariate and multivariate meta-regressions were done to predict sources of between-study heterogeneity. Overall, the pooled prevalence of TB/HIV coinfection was 25.8%. The highest coinfection prevalence of 34.3% was recorded among the North Central States of Nigeria, while the least prevalence of 19.3% was recorded among the Southeastern states of Nigeria. There was a paucity of published articles from the Northeastern states of Nigeria. There was a significant heterogeneity between studies (I2 > 90%, p < 0.001), but meta-regression analysis only explained < 10% of it. This study has shown that the prevalence of TB/HIV coinfection remains significantly high in Nigeria. Constant surveillance should be rigorously implemented with special attention given to the Northeast due to the ongoing crises that are compounding the problem.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.