血小板微粒处理的内皮祖细胞移植改善大鼠子痫前期模型胎盘血管修复。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2020-11-01 Epub Date: 2020-10-23 DOI:10.1080/10641955.2020.1833914

Zhenya Fang, Anna Li, Yaqiong Sun, Xietong Wang, Meihua Zhang

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引用次数: 2

摘要

目的:探讨血小板微粒(pmp)处理内皮祖细胞(EPCs)在子痫前期的作用。方法:对经/不经pmp处理的EPCs进行标记并注射PE大鼠。测定各组EPCs分化、内皮型一氧化氮合酶(eNOS)、血压和蛋白尿的变化。各PE组血压和蛋白尿升高，EPCs改善，pmp增强。内皮祖细胞移植可促进胎盘血管生成。一氧化氮变化趋势与血压变化趋势一致。结论:pmp治疗EPCs移植能有效改善血压和蛋白尿。

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Improved placental vascular repair in a rat preeclampsia model by implantation of endothelial progenitor cells treated with platelet microparticles.

Objective: To detect the role of endothelial progenitor cells (EPCs) treated with platelet microparticles (PMPs) in preeclampsia. Methods: EPCs treated with/without PMPs were labeled and injected to PE rats. The differentiation of EPCs, the change of endothelial nitric oxide synthase (eNOS), blood pressure and proteinuria were measured. The blood pressure and proteinuria increased in each of PE groups, and were improved by EPCs which was strengthened by PMPs. Transplantation of EPCs increased placental angiogenesis. The trend of change of NO was the same as blood pressure. Conclusion: Transplantation of EPCs treated with PMPs improved blood pressure and proteinuria more effectively.

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.