弥漫性胃癌：疾病的组织学、分子和遗传基础。

IF 3 4区医学 Q1 Medicine

Translational gastroenterology and hepatology Pub Date : 2020-10-05 eCollection Date: 2020-01-01 DOI:10.21037/tgh.2020.01.02

Pritish Iyer, Maitham Moslim, Jeffrey M Farma, Crystal S Denlinger

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引用次数: 0

摘要

弥漫性胃癌（DGC）是一种独特的组织病理学和分子疾病，以 CDH1、RHOA 等基因突变为特征。此外，DGC 还与家族综合征有关，包括遗传性 DGC 和 CDH1 基因突变。在临床上，这种亚型胃腺癌的预后较差，并可能对现有的全身疗法产生抗药性。了解 DGC 的遗传和分子基础有助于了解其临床表现，并有助于筛查、诊断和治疗反应。在本综述中，我们将回顾 DGC 目前的组织学、分子和遗传学状况及其与临床实践的相关性。

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Diffuse gastric cancer: histologic, molecular, and genetic basis of disease.

Diffuse gastric cancer (DGC) is a distinct histopathologic and molecular disease, characterized by mutations in CDH1, RHOA, and others. In addition, DGC is associated with familial syndromes, including hereditary DGC and germline mutation in CDH1. Clinically, this subtype of gastric adenocarcinoma is associated with a poor prognosis and possible resistance to available systemic therapies. An understanding of the genetic and molecular underpinnings of DGC may help inform of its clinical behavior and aid in screening, diagnosis, and response to treatment. In this review, we will review the current histologic, molecular, and genetic landscape of DGC and its relevance to clinical practice.

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来源期刊

Translational gastroenterology and hepatology Medicine-Gastroenterology

CiteScore

8.20

自引率

0.00%

发文量

期刊介绍： Translational Gastroenterology and Hepatology (Transl Gastroenterol Hepatol; TGH; Online ISSN 2415-1289) is an open-access, peer-reviewed online journal that focuses on cutting-edge findings in the field of translational research in gastroenterology and hepatology and provides current and practical information on diagnosis, prevention and clinical investigations of gastrointestinal, pancreas, gallbladder and hepatic diseases. Specific areas of interest include, but not limited to, multimodality therapy, biomarkers, imaging, biology, pathology, and technical advances related to gastrointestinal and hepatic diseases. Contributions pertinent to gastroenterology and hepatology are also included from related fields such as nutrition, surgery, public health, human genetics, basic sciences, education, sociology, and nursing.