变异rs3774261非g等位基因携带者在地中海饮食模式后血脂和脂联素的改善

IF 2 4区 医学 Q3 GENETICS & HEREDITY
Lifestyle Genomics Pub Date : 2020-01-01 Epub Date: 2020-10-19 DOI:10.1159/000508819
Daniel A de Luis, David Primo, Olatz Izaola, Emilia Gómez, Rosario Bachiller
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引用次数: 5

摘要

背景:脂联素(ADIPOQ)多态性在不同饮食干预后体重减轻和血脂变化中的作用尚不清楚。在不同的研究中,地中海饮食模式与改善心血管风险因素有关。目的:我们的目的是分析低热量饮食和地中海饮食模式对代谢反应和肥胖参数的影响,同时考虑到ADIPOQ的712 G/ a rs3774261多态性。设计:纳入135例肥胖患者。在饮食干预前后(12周)测量人体测量和血清参数(血脂、胰岛素、胰岛素抵抗稳态模型评估[HOMA-IR]、葡萄糖、c -反应蛋白[CRP]、脂联素、抵抗素和瘦素水平)。所有患者均进行rs3774261多态性基因分型。结果:AA型36例(26.7%),AG型68例(50.4%),GG型31例(22.9%)。在饮食干预后,两种基因型的BMI、体重、脂肪量、收缩压、腰围、葡萄糖、胰岛素、HOMA-IR和瘦素水平均下降。饮食干预后继发性体重减轻和非g等位基因携带者(AA vs AG+GG),总胆固醇(Δ = -15.7±3.9 vs -4.9±2.9 mg/dL;p = 0.02), LDL胆固醇(Δ = -15.3±3.8 vs. -1.7±1.9 mg/dL;p = 0.01),甘油三酯水平(Δ = -23.4±5.6 vs. 2.3±2.3 mg/dL;p = 0.01)和c反应蛋白(Δ= -1.1±0.1和-0.4±0.2 mg / dL;P = 0.01)降低。脂联素水平(Δ = 7.2±2.1 vs. -0.4±0.3 ng/dL;P = 0.02)升高。值得注意的是,g等位基因携带者没有表现出这种改善。结论:ADIPOQ变体(rs3774261)的非g等位基因携带者在低热量饮食和地中海饮食模式下,血清脂联素水平、脂质谱和CRP水平显著改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum Lipid and Adiponectin Improvements after a Mediterranean Dietary Pattern in Non-G-Allele Carriers of the Variant rs3774261.

Background: The role of adiponectin (ADIPOQ) polymorphisms in weight loss and serum lipid changes following different dietary interventions remain unclear. The Mediterranean dietary pattern has been associated with improved cardiovascular risk factors in different studies.

Objective: Our aim was to analyze the effects of a hypocaloric diet with a Mediterranean dietary pattern on the metabolic response and adiposity parameters, taking into account the 712 G/A rs3774261 polymorphisms in ADIPOQ.

Design: A population of 135 obese patients was enrolled. Anthropometric and serum parameters (lipid profile, insulin, homeostasis model assessment for insulin resistance [HOMA-IR], glucose, C-reactive protein [CRP], adiponectin, resistin, and leptin levels) were measured before and after the dietary intervention (12 weeks). All of the patients were genotyped for the rs3774261 polymorphism.

Results: The genotype distribution of this population was 36 patients with AA (26.7%), 68 patients with AG (50.4%), and 31 patients with GG (22.9%). After the dietary intervention and in both genotypes, BMI, weight, fat mass, systolic blood pressure, waist circumference, glucose, insulin, HOMA-IR, and leptin levels all decreased. After the dietary intervention with secondary weight loss and in non-G-allele carriers (AA vs. AG+GG), total cholesterol (Δ = -15.7 ± 3.9 vs. -4.9 ± 2.9 mg/dL; p = 0.02), LDL cholesterol (Δ = -15.3 ± 3.8 vs. -1.7 ± 1.9 mg/dL; p = 0.01), triglyceride levels (Δ = -23.4 ± 5.6 vs. 2.3 ± 2.3 mg/dL; p = 0.01), and CRP (Δ = -1.1 ± 0.1 vs. -0.4 ± 0.2 mg/dL; p = 0.01) decreased. Adiponectin levels (Δ = 7.2 ± 2.1 vs. -0.4 ± 0.3 ng/dL; p = 0.02) increased. Notably, G-allele carriers did not show this improvement.

Conclusion: Non-G-allele carriers of the ADIPOQ variant (rs3774261) showed significant improvement in serum levels of adiponectin, lipid profiles, and CRP in response to a hypocaloric diet with a Mediterranean dietary pattern.

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来源期刊
Lifestyle Genomics
Lifestyle Genomics Agricultural and Biological Sciences-Food Science
CiteScore
4.00
自引率
7.70%
发文量
11
审稿时长
28 weeks
期刊介绍: Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.
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