患者对重度抑郁症认知症状的看法:回顾性数据库和前瞻性调查分析。

Q2 Medicine
Emil Chiauzzi, Jennifer Drahos, Sara Sarkey, Christopher Curran, Victor Wang, Dapo Tomori
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引用次数: 0

摘要

背景:重度抑郁障碍(MDD)是一种常见且负担沉重的疾病。临床上对重度抑郁症的认识是由目前的研究决定的,而这些研究缺乏对患者视角的洞察:本研究由两部分组成,旨在从在线患者网络 PatientsLikeMe 中获取数据,了解患者对 MDD 认知症状的看法及其优先级:采用回顾性数据分析(研究 1)来分析 PatientsLikeMe 社区中自述患有 MDD 的患者的数据。研究分析了患者人口统计学、合并症、自评 MDD 严重程度、治疗效果以及 MDD 具体症状等信息。通过电子邮件向 PatientsLikeMe MDD 社区的长期成员和近期活跃成员发送了前瞻性电子调查(研究 2)。研究 1 的分析为研究 2 的调查目标提供了依据,研究 2 的目标是确定症状感知和优先级、MDD 的认知症状、残留症状和药物治疗效果:在研究 1(样本数=17,166)中,认知症状被频繁报告,其中包括 "严重 "的集中注意力困难(28%)。即使是无抑郁症/轻度抑郁症患者(80%)和认为治疗成功的患者(17%)也有集中注意力困难的报告。在研究 2(N=2525)中,23% 的患者(118/508)将认知症状列为治疗重点。认知症状与抑郁严重程度相关,包括难以做出决定、难以集中注意力和难以清晰思考(rs 分别为 0.32、0.36 和 0.34)。认知症状干扰了有意义的人际关系和日常生活任务,并对患者的工作能力和抑郁症康复能力产生了深远影响:患者承认,多发性抑郁症的认知功能障碍限制了他们完全康复并恢复正常社会和职业功能的能力。为了帮助患者恢复正常的认知功能,帮助他们全面康复,临床上需要进一步了解和描述 MDD 的症状优先级和残余认知障碍导致的复发风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Patient Perspective of Cognitive Symptoms in Major Depressive Disorder: Retrospective Database and Prospective Survey Analyses.

Patient Perspective of Cognitive Symptoms in Major Depressive Disorder: Retrospective Database and Prospective Survey Analyses.

Patient Perspective of Cognitive Symptoms in Major Depressive Disorder: Retrospective Database and Prospective Survey Analyses.

Patient Perspective of Cognitive Symptoms in Major Depressive Disorder: Retrospective Database and Prospective Survey Analyses.

Background: Major depressive disorder (MDD) is a common and burdensome condition. The clinical understanding of MDD is shaped by current research, which lacks insight into the patient perspective.

Objective: This two-part study aimed to generate data from PatientsLikeMe, an online patient network, on the perception of cognitive symptoms and their prioritization in MDD.

Methods: A retrospective data analysis (study 1) was used to analyze data from the PatientsLikeMe community with self-reported MDD. Information on patient demographics, comorbidities, self-rated severity of MDD, treatment effectiveness, and specific symptoms of MDD was analyzed. A prospective electronic survey (study 2) was emailed to longstanding and recently active members of the PatientsLikeMe MDD community. Study 1 analysis informed the objectives of the study 2 survey, which were to determine symptom perception and prioritization, cognitive symptoms of MDD, residual symptoms, and medication effectiveness.

Results: In study 1 (N=17,166), cognitive symptoms were frequently reported, including "severe" difficulty in concentrating (28%). Difficulty in concentrating was reported even among patients with no/mild depression (80%) and those who considered their treatment successful (17%). In study 2 (N=2525), 23% (118/508) of patients cited cognitive symptoms as a treatment priority. Cognitive symptoms correlated with depression severity, including difficulty in making decisions, concentrating, and thinking clearly (rs=0.32, 0.36, and 0.34, respectively). Cognitive symptoms interfered with meaningful relationships and daily life tasks and had a profound impact on patients' ability to work and recover from depression.

Conclusions: Patients acknowledge that cognitive dysfunction in MDD limits their ability to recover fully and return to a normal level of social and occupational functioning. Further clinical understanding and characterization of MDD for symptom prioritization and relapse risk due to residual cognitive impairment are required to help patients return to normal cognitive function and aid their overall recovery.

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来源期刊
Journal of Participatory Medicine
Journal of Participatory Medicine Medicine-Medicine (miscellaneous)
CiteScore
3.20
自引率
0.00%
发文量
8
审稿时长
12 weeks
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