下一代测序在胃或胃食管腺癌中的应用。

IF 3 4区医学 Q1 Medicine

Translational gastroenterology and hepatology Pub Date : 2020-10-05 eCollection Date: 2020-01-01 DOI:10.21037/tgh.2020.01.09

Geoffrey Y Ku

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引用次数: 4

摘要

癌症基因组图谱(TGCA)和亚洲癌症研究小组(ACRG)的开创性分析为胃癌(GC)的分子基础提供了前所未有的见解。与此同时，下一代测序(NGS)面板，由DNA测序技术和生物信息学的量子改进驱动，现在常规用于标准临床护理，也广泛用于研究目的。本文将对胃癌的分子亚型、目前胃癌的标准治疗方法以及NGS在标准治疗和研究中的作用进行综述。

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Next generation sequencing in gastric or gastroesophageal adenocarcinoma.

Seminal analyses of The Cancer Genome Atlas (TGCA) and Asian Cancer Research Group (ACRG) have provided unprecedented insight into the molecular underpinnings of gastric cancer (GC). At the same time, next generation sequencing (NGS) panels, driven by quantum improvements in DNA sequencing technology and bioinformatics, are now routinely used in standard clinical care and also extensively for research purposes. This review article will discuss the molecular subtypes of GC, the current standard-of-care therapies for GC and the role of NGS in standard care and in research.

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来源期刊

Translational gastroenterology and hepatology Medicine-Gastroenterology

CiteScore

8.20

自引率

0.00%

发文量

期刊介绍： Translational Gastroenterology and Hepatology (Transl Gastroenterol Hepatol; TGH; Online ISSN 2415-1289) is an open-access, peer-reviewed online journal that focuses on cutting-edge findings in the field of translational research in gastroenterology and hepatology and provides current and practical information on diagnosis, prevention and clinical investigations of gastrointestinal, pancreas, gallbladder and hepatic diseases. Specific areas of interest include, but not limited to, multimodality therapy, biomarkers, imaging, biology, pathology, and technical advances related to gastrointestinal and hepatic diseases. Contributions pertinent to gastroenterology and hepatology are also included from related fields such as nutrition, surgery, public health, human genetics, basic sciences, education, sociology, and nursing.