血清瘦素作为子宫内膜异位症严重程度的标志物。

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY
Obstetrics and Gynecology International Pub Date : 2020-09-07 eCollection Date: 2020-01-01 DOI:10.1155/2020/6290693
Shatha Sami Hussein, Fatin Shallal Farhan, Alaa Ibrahim Ali
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引用次数: 4

摘要

背景:子宫内膜异位症是一种理论上的疾病,是慢性盆腔疼痛、痛经、性交困难和生育能力低下的重要原因之一。手术是诊断的主要步骤;无创检测是未来的目标。研究目的:探讨血清瘦素在子宫内膜异位症严重程度判定中的作用。研究设计。2018年1月1日至2019年1月1日在Al-Yarmouk教学医院进行的横断面研究。方法:60例bmi指标匹配的患者参与研究。研究组有30例因多种原因经组织病理学诊断为子宫内膜异位症的患者,分别行腹腔镜或开腹手术,对照组有30例正常妇女行择期手术。腹腔镜检查发现为子宫内膜异位症的所有患者均在手术室采血,根据子宫内膜异位症的手术分期,采用ELISA法检测血清瘦素(Human LEP (leptin) ELISA Kit)。将组织病理学诊断符合后的腹腔镜检查记录与血清瘦素检测结果进行比较。结果:两组在胎次和年龄上无显著差异;然而,血清瘦素水平在子宫内膜异位症组明显高于对照组。P值均小于0.05。结果显示,两组患者的血清瘦素按症状分无显著差异,但按手术分期有显著差异。1期血清瘦素均值为214.8,4期血清瘦素均值为340.3。结论:血清瘦素可作为判断子宫内膜异位症严重程度的指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Serum Leptin as a Marker for Severity of Endometriosis.

Serum Leptin as a Marker for Severity of Endometriosis.

Serum Leptin as a Marker for Severity of Endometriosis.

Background: Endometriosis a disease of theories, and one of the important causes of chronic pelvic pain, dysmenorrhea, dyspareunia, and subfertility. Surgery is the mainstay step for the diagnosis; noninvasive test is the goal in the future. Aim of Study. To test the role of serum leptin in determination of severity of endometriosis. Study Design. A cross-sectional study done in Al-Yarmouk Teaching Hospital from 1st of January 2018 to 1st of January 2019.

Methods: 60 BMI-matched patients were involved in the study. A study group of 30 patients were operated either by laparoscopy or laparotomy for many reasons diagnosed as endometriosis by histopathology, and 30 normal women as a control group underwent elective surgery. Blood sample was taken from all patients in the theater room when laparoscopy finding went with endometriosis, and classifying according to surgical staging of endometriosis, the level of serum leptin was measured by ELISA using Human LEP (Leptin) ELISA Kit. The recording of finding of laparoscopy after conforming of diagnosis by histopathology was compared with the result of serum leptin.

Result: The result shows no significant difference between the two groups regarding parity and age; however, the level of serum leptin was significantly high in the endometriosis group than in the control group. The P value was less than 0.05. Also, the result shows no significant differences between serum leptin in both groups according to the symptom but there was a significant difference with surgical staging. The mean of the level of serum leptin in stage 1 was 214.8, while it was 340.3 in stage 4.

Conclusion: Serum leptin can be used as a marker of severity of endometriosis.

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来源期刊
Obstetrics and Gynecology International
Obstetrics and Gynecology International OBSTETRICS & GYNECOLOGY-
CiteScore
3.60
自引率
0.00%
发文量
26
审稿时长
19 weeks
期刊介绍: Obstetrics and Gynecology International is a peer-reviewed, Open Access journal that aims to provide a forum for scientists and clinical professionals working in obstetrics and gynecology. The journal publishes original research articles, review articles, and clinical studies related to obstetrics, maternal-fetal medicine, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine and infertility, reproductive endocrinology, and sexual medicine.
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