转移蛋白作为伊拉克多囊卵巢综合征妇女高雄激素血症的标志物。

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY
Obstetrics and Gynecology International Pub Date : 2020-09-25 eCollection Date: 2020-01-01 DOI:10.1155/2020/5216903
Manal Madany Abdalqader, Shatha Sami Hussein
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引用次数: 1

摘要

目的:Kisspeptin 1可能反映多囊卵巢综合征患者雄激素水平升高,而非其他指标。研究设计。2016年7月1日至2017年7月1日在Al-Yarmouk教学医院进行病例对照研究;87名女性被分为两组:44名诊断为多囊卵巢综合征的女性,22名BMI≥25 kg/m2的女性和22名BMI为2的女性,另外43名非多囊卵巢综合征的女性,22名BMI≥25 kg/m2的女性和21名BMI为2的女性。使用人kisspeptin 1(KISS-1)酶联免疫吸附测定试剂盒评估激素、代谢谱、多毛症评分以及血清kisspeptin水平。月经周期第2天至第5天的血样由一次性无菌注射器抽取,并在含有EDTA的试管中收集(作为抗凝剂),使用生物技术ELISA阅读器测量激素谱。结果:PCOS患者血清kisspeptin水平显著高于对照组(分别为322.4 ng/L和235.3 ng/L)。对照组和多囊卵巢综合征患者在年龄、BMI和胎次方面无显著差异;多囊卵巢综合征患者多毛、痤疮、黄体生成素升高和游离睾酮(fTT)升高的频率明显高于对照组。Kisspeptin与多毛症、fTT有直接显著相关(r分别为0.648、0.238)。在ROC分析中,kisspeptin预测PCOS的AUC (95% CI) = 0.874(0.785-0.935)。结论:Kisspeptin水平可作为多囊卵巢综合征高雄激素血症的标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome.

Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome.

Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome.

Metastatin as a Marker for Hyperandrogenemia in Iraqi Women with Polycystic Ovary Syndrome.

Objective: Kisspeptin 1 might reflect increased androgen level in polycystic ovarian syndrome instead of other markers. Study Design. A case control study was performed in Al-Yarmouk Teaching Hospital from 1st of July 2016 to 1st of July 2017; it involved 87 women divided into two groups: 44 women diagnosed as PCOS, 22 women with BMI ≥ 25 kg/m2 and 22 women with BMI < 25 kg/m2, and another 43 women without PCOS, 22 women with BMI ≥ 25 kg/m2 and 21 women with BMI < 25 kg/m2. Hormonal, metabolic profiles, and hirsutism scores, as well as serum kisspeptin level, were assessed by using Human Kisspeptin 1(KISS-1) ELISA Kit. The blood samples between days 2 and 5 of menstrual cycle were drawn by an disposable sterile syringe and collected in EDTA containing tubes (as anticoagulant), and the hormonal profile was measured using a biotech ELISA reader.

Result: Serum level of kisspeptin was significantly higher in PCOS compared to control (322.4 vs. 235.3 ng/L, respectively). There was no significant difference in age, BMI, and parity between control and PCOS; the frequency of hirsutism, acne, elevated LH, and increased free testosterone (fTT) were significantly higher in PCOS compared to control. Kisspeptin shows a direct significant correlation with hirsutism and fTT (r = 0.648, 0.238, respectively). In ROC analysis, kisspeptin had AUC (95% CI) = 0.874 (0.785-0.935) for predicting PCOS.

Conclusion: Kisspeptin levels might be used as a marker for hyperandrogenemia in polycystic ovarian syndrome.

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来源期刊
Obstetrics and Gynecology International
Obstetrics and Gynecology International OBSTETRICS & GYNECOLOGY-
CiteScore
3.60
自引率
0.00%
发文量
26
审稿时长
19 weeks
期刊介绍: Obstetrics and Gynecology International is a peer-reviewed, Open Access journal that aims to provide a forum for scientists and clinical professionals working in obstetrics and gynecology. The journal publishes original research articles, review articles, and clinical studies related to obstetrics, maternal-fetal medicine, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine and infertility, reproductive endocrinology, and sexual medicine.
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