Deborah A Silverman, George A Calin, Jeffrey N Myers, Moran Amit
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Neural reprogramming via microRNAs: the new kid on the p53-deficient block.
We recently reported a novel role for nerve-cancer crosstalk, demonstrating that tumor protein p53 (TP53) deficiency in head and neck squamous cell carcinoma leads to a decrease in miR-34a in tumor-shed vesicles. This directed sensory nerve reprogramming in the tumor microenvironment which enhanced tumor growth.
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