microrna在多发性硬化中的作用。

IF 4.3 4区医学 Q2 IMMUNOLOGY

International Reviews of Immunology Pub Date : 2022-01-01 Epub Date: 2020-09-30 DOI:10.1080/08830185.2020.1826474

Sahar Rostami Mansoor, Maryam Ghasemi-Kasman, Hanie Yavarpour-Bali

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引用次数: 6

摘要

尽管对多发性硬化症(MS)进行了大量研究，并了解了这种疾病的许多方面，但研究人员仍在努力寻找合适的生物标志物来促进诊断;MicroRNAs (miRNAs)被认为是内源性的、相对稳定的、小的非编码rna，参与多种生物和病理信号通路。有趣的是，mirna已成为监测MS患者新疗法的潜在生物标志物。在这篇综述中，我们描述了MS患者中miRNAs的改变，以及它们在常规MS治疗下的表达改变。

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The role of microRNAs in multiple sclerosis.

Despite numerous studies on multiple sclerosis (MS) and understanding many aspects of this disease, researchers still struggle to find proper biomarkers that facilitate diagnosis; prognosis and monitoring of treatment efficacy in MS. MicroRNAs (miRNAs) are considered as endogenous, comparatively stable and small non-coding RNAs involved in various biological and pathological signaling pathways. Interestingly, miRNAs have been emerged as a potential biomarker for monitoring novel therapies in MS patients. In this review, we described the miRNAs alteration in the MS patients as well as their altered expression in patients under common MS therapies.

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来源期刊

International Reviews of Immunology 医学-免疫学

CiteScore

11.00

自引率

4.00%

发文量

期刊介绍： This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).