与获得性免疫缺陷综合征相关的巴西副球虫S1引起的副球虫菌病:1例报告

IF 1.5 4区生物学 Q4 MYCOLOGY

Revista Iberoamericana De Micologia Pub Date : 2021-01-01 DOI:10.1016/j.riam.2020.09.003

Paulo Mendes Peçanha , Isabela Cruz Bahiense , Wdson Luis Lima Kruschewsky , Cláudia Biasutti , Carlos Urbano Gonçalves Ferreira Júnior , Breno Gonçalves Pinheiro , Simone Bravim Maifrede , Zoilo Pires de Camargo , Anderson Messias Rodrigues , Tânia Regina Grão-Velloso , Aloísio Falqueto , Sarah Santos Gonçalves

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引用次数: 3

摘要

背景:副球孢子菌病(PCM)是拉丁美洲的一种地方病。在免疫正常的宿主中，PCM主要表现为两种临床形式:急性和慢性。然而，在hiv感染的患者中，PCM可能同时表现为急性和慢性形式。病例报告:我们报告了一例被诊断为HIV的患者，他有弥散性皮肤病变和全身性淋巴结病，以及呼吸和中枢神经系统受累。PCM的诊断是通过直接KOH检查，双重免疫扩散和分离真菌的样本在肋下区域脓肿。采用蛋白编码基因GP43(外显子2)引物和α -微管蛋白基因的PCR- rflp进行种特异性PCR鉴定，该分离物为巴西副球蚴S1。结论文献报道HIV/PCM患者中副球虫的种特异性分子鉴定资料较少。因此，本病例报告可能有助于提高对这种严重疾病、其致病隐种及其对患者后果的认识。

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Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 associated with acquired immunodeficiency syndrome: A case report

Background

Paracoccidioidomycosis (PCM) is an endemic disease in Latin America. In immunocompetent hosts, PCM occurs in two main clinical forms: acute and chronic. However, in HIV-infected patients PCM may show up simultaneous manifestations of acute and chronic forms.

Case report

We present the case of a patient diagnosed with HIV who had disseminated skin lesions and generalized lymphadenopathy, as well as respiratory and central nervous system involvement. The PCM diagnosis was confirmed by direct KOH examination, double immunodiffusion and the isolation of the fungus in samples of an abscess in the subcostal region. The isolate was identified as Paracoccidioides brasiliensis S1 by species-specific PCR using primers for protein-coding gene GP43 (exon 2) followed by PCR-RFLP of the alpha-tubulin gene.

Conclusions

There are few data in literature reporting species-specific molecular identification of Paracoccidioides in HIV/PCM patients. Therefore, this case report may contribute to improve the knowledge about this severe disease, its causative cryptic species, and its consequences to patients.

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来源期刊

Revista Iberoamericana De Micologia MYCOLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

81 days

期刊介绍： Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.