荆芥及其作为动脉粥样硬化草药的潜在用途:来自细胞和啮齿动物研究的机制见解。

IF 2 4区 医学 Q3 GENETICS & HEREDITY
Lifestyle Genomics Pub Date : 2020-01-01 Epub Date: 2020-09-03 DOI:10.1159/000508818
Ting Xiao, Jiaoyan Huang, Xiaowei Wang, Linjing Wu, Xue Zhou, Feng Jiang, Zhiyong He, Qianqian Guo, Ling Tao, Xiangchun Shen
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引用次数: 7

摘要

背景/目的:Alpinia zerumbet (Pers.)伯特。几个世纪以来,它一直被用作食品中的风味添加剂和传统药物,特别是在中国贵州省,它具有多种有益的作用,可以延长人们的寿命。因此,本综述的目的之一是阐述这种植物的化学成分,特别是其果实。由于心血管疾病,包括动脉粥样硬化,对人类健康构成威胁,另一个目的是阐明其作为治疗动脉粥样硬化的草药的潜在用途的可能机制。方法:引用10篇文献对其潜在的生物活性成分进行阐述。此外,有33篇报道通过改善炎症和内皮功能障碍、增加血管舒张、改善高脂血症、降低葡萄糖状态和作为抗氧化剂来解释这种植物的抗高血压和抗动脉粥样硬化作用。结果:莪术中含有丰富的萜类、精油、黄酮类、多酚类和甾醇。药理实验表明,枳实对NF-κB信号通路具有抗氧化和抗炎作用,对NOS-NO信号通路的氧化应激有改善作用。此外,枳实通过加速血管舒张反应和增加细胞内3T3-L1 cAMP,显示出抗高血压作用,具有良好的抗肥胖特性,以及降血脂和抗糖尿病并发症的作用。结论:枳实在预防动脉粥样硬化方面具有潜在的功能和应用,但在临床试验前还需进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alpinia zerumbet and Its Potential Use as an Herbal Medication for Atherosclerosis: Mechanistic Insights from Cell and Rodent Studies.

Background/aims: Alpinia zerumbet (Pers.) Burtt. et Smith has been used as a flavor additive in food and a traditional medicine for centuries, especially in Guizhou Province, China, and it prolongs people's lives with multiple beneficial effects. Thus, one of the aims of this review was to expound the chemical constituents of this plant, especially its fruits. Since cardiovascular diseases, including atherosclerosis, pose a health threat to humans, another aim was to expound the possible mechanisms of its potential use as an herbal medication for atherosclerosis.

Methods: In this study, 10 reports are cited to expound the potential bioactive compounds. Moreover, 33 reports explain the antihypertensive and antiatherosclerotic effects of the plant by ameliorating inflammation and endothelial dysfunction, increasing vasodilation, improving hyperlipidemia, downgrading the glucose status, and working as an antioxidant.

Results: A. zerumbetis rich in terpenes, essential oils, flavonoids, polyphenolics, and sterols. Pharmacological experiments showed that A. zerumbet has antioxidative and anti-inflammatory effects on the NF-κB signaling pathway and can ameliorate oxidative stress in the NOS-NO signaling pathway. Moreover, A. zerumbet demonstrates antihypertensive effects by accelerating vasorelaxant response and increasing 3T3-L1 intracellular cAMP, which has promising antiobesity properties, as well as hypolipidemic and anti-diabetic complication effects.

Conclusions: A. zerumbet has potential functions and applications in the prevention of atherosclerosis, but further studies are required before clinical trials.

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来源期刊
Lifestyle Genomics
Lifestyle Genomics Agricultural and Biological Sciences-Food Science
CiteScore
4.00
自引率
7.70%
发文量
11
审稿时长
28 weeks
期刊介绍: Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.
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