ADAM9的结构、调控因子及肿瘤相关生理作用。

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
M A Haoyuan, L I Yanshu
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引用次数: 4

摘要

ADAMs家族属于锌依赖性金属蛋白酶跨膜蛋白超家族,由多个结构域组成。这些结构域具有独立但互补的功能,使它们能够参与多种生物过程。其中ADAM9不仅可以作为金属蛋白酶参与细胞外基质的降解,还可以通过其去整合素结构域介导肿瘤细胞粘附,与肿瘤侵袭转移密切相关。它广泛表达于多种肿瘤细胞中,可影响相关癌细胞的增殖、侵袭和转移。我们提供了我们对目前进展的看法,其作为战略治疗目标的重要性日益增加,以及我们对ADAM9未来的展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Structure, regulatory factors and cancer-related physiological effects of ADAM9.

Structure, regulatory factors and cancer-related physiological effects of ADAM9.

Structure, regulatory factors and cancer-related physiological effects of ADAM9.

Structure, regulatory factors and cancer-related physiological effects of ADAM9.

The ADAMs family belongs to the transmembrane protein superfamily of zinc-dependent metalloproteases, which consists of multiple domains. These domains have independent but complementary functions that enable them to participate in multiple biological processes. Among them, ADAM9 can not only participate in the degradation of extracellular matrix as a metalloprotease, but also mediate tumor cell adhesion through its deintegrin domain, which is closely related to tumor invasion and metastasis. It is widely expressed in a variety of tumor cells and can affect the proliferation, invasion and metastasis of related cancer cells. We provide our views on current progress, its increasing importance as a strategic treatment goal, and our vision for the future of ADAM9.

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来源期刊
CiteScore
6.40
自引率
0.00%
发文量
7
审稿时长
53 weeks
期刊介绍: Cell Adhesion & Migration is a multi-disciplinary, peer reviewed open access journal that focuses on the biological or pathological implications of cell-cell and cell-microenvironment interactions. The main focus of this journal is fundamental science. The journal strives to serve a broad readership by regularly publishing review articles covering specific disciplines within the field, and by publishing focused issues that provide an overview on specific topics of interest within the field. Cell Adhesion & Migration publishes relevant and timely original research, as well as authoritative overviews, commentaries, and perspectives, providing context for the work presented in Cell Adhesion & Migration and for key results published elsewhere. Original research papers may cover all topics important in the field of cell-cell and cell-matrix interactions. Cell Adhesion & Migration also publishes articles related to cell biomechanics, biomaterial, and development of related imaging technologies.
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