巨噬细胞与肠道共生。

Q4 Biochemistry, Genetics and Molecular Biology

Results and Problems in Cell Differentiation Pub Date : 2020-01-01 DOI:10.1007/978-3-030-51849-3_23

Malgorzata Kloc, Ahmed Uosef, Mahmoud Elshawwaf, Ahmed Adel Abbas Abdelshafy, Kamal Mamdoh Kamal Elsaid, Jacek Z Kubiak, Rafik Mark Ghobrial

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引用次数: 1

摘要

人体肠道中栖息着数以万亿计的微生物，并拥有人体中最大的巨噬细胞池。巨噬细胞作为先天免疫系统的一部分，对肠道中存在的微生物和膳食抗原产生强烈反应。由于这种强大的免疫反应对肠道有益和无害菌群的生存构成威胁，巨噬细胞形成了对肠道有益和无害菌群的识别和低敏感性机制。我们将在下一章讨论其中一些机制的演变和特性。

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The Macrophages and Intestinal Symbiosis.

The human intestinal tract is inhabited by trillions of microorganisms and houses the largest pool of macrophages in the human body. Being a part of the innate immune system, the macrophages, the professional phagocytes, vigorously respond to the microbial and dietary antigens present in the intestine. Because such a robust immune response poses the danger to the survival of the non-harmful and beneficial gut microbiota, the macrophages developed mechanisms of recognition and hyposensitivity toward the non-harmful/beneficial inhabitants of the gut. We will discuss the evolution and identity of some of these mechanisms in the following chapter.

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来源期刊

Results and Problems in Cell Differentiation Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Results and Problems in Cell Differentiation is an up-to-date book series that presents and explores selected questions of cell and developmental biology. Each volume focuses on a single, well-defined topic. Reviews address basic questions and phenomena, but also provide concise information on the most recent advances. Together, the volumes provide a valuable overview of this exciting and dynamically expanding field.