维生素D缺乏引起的无症状心肌功能障碍。

Pelin Karaca Ozer, Samim Emet, Ekrem Bilal Karaayvaz, Ali Elitok, Ahmet Kaya Bilge, Kamil Adalet, Aytac Oncul
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引用次数: 7

摘要

简介:维生素D (VD)缺乏是一种常见病,发生在生命的各个阶段。越来越多的研究呼吁关注VD缺乏与心血管疾病之间的关系。本研究的目的是探讨VD对无明显冠状动脉疾病的糖尿病和非糖尿病患者亚临床左心室(LV)功能的影响。材料和方法:我们招募140例有稳定型缺血性心脏病症状的患者(80例糖尿病患者,60例非糖尿病患者),均行冠状动脉造影,且临床无明显冠状动脉疾病。测量25(OH)D3水平,将25-(OH)D3水平低于20 ng/dl的患者定义为VD缺乏组。除常规超声心动图参数外,采用组织多普勒超声心动图检测左室舒张功能,二维斑点跟踪应变超声心动图(2D STE)评价左室心肌纵向变形指标。结果:在所有组中,与没有VD缺乏的患者相比,VD缺乏患者的左室整体纵向应变(GLS)显著受损(p < 0.001)。VD缺乏患者左室整体纵向应变率(GLSR)显著降低(p = 0.003)。VD缺乏组GLS与25-(OH)D3呈负相关(r = -0.52623, p < 0.001)。相反,正常VD组GLS与25-(OH)D3水平呈正相关(r = 0.28, p = 0.048)。结论:VD缺乏与心肌GLS受损相关。本研究表明,VD缺乏可能是无显著冠状动脉疾病史的糖尿病或非糖尿病患者亚临床心肌功能障碍的原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Silent myocardial dysfunction in vitamin D deficiency.

Silent myocardial dysfunction in vitamin D deficiency.

Silent myocardial dysfunction in vitamin D deficiency.

Silent myocardial dysfunction in vitamin D deficiency.

Introduction: Vitamin D (VD) deficiency is a common disease that occurs in all stages of life. A growing number of studies call attention to the relationship between VD deficiency and cardiovascular disease. The aim of this study was to investigate the effect of VD on subclinical left ventricular (LV) function in diabetic and non-diabetic patients with no significant coronary artery disease.

Material and methods: We recruited 140 patients (80 diabetics and 60 non-diabetics) with symptoms of stable ischemic heart disease who underwent coronary angiography and who had no significant coronary artery disease in our clinic. The 25(OH)D3 levels were measured and patients who had 25-(OH)D3 levels below 20 ng/dl were defined as the VD deficient group. In addition to conventional echocardiographic parameters, tissue Doppler echocardiography was used for LV diastolic functions and 2D speckle tracking strain echocardiography (2D STE) for evaluating the longitudinal deformation indices of the LV myocardium.

Results: In all groups, LV global longitudinal strain (GLS) was significantly impaired in patients with VD deficiency (p < 0.001) compared to patients without VD deficiency. LV global longitudinal strain rate (GLSR) was significantly impaired in patients with VD deficiency (p = 0.003). The GLS was negatively associated with 25-(OH)D3 in the VD deficiency group (r = -0.52623, p < 0.001). Conversely, GLS was positively associated with 25-(OH)D3 levels in the normal VD group (r = 0.28, p = 0.048).

Conclusions: VD deficiency is associated with impaired myocardial GLS. The present study demonstrated that VD deficiency may be the cause of subclinical myocardial dysfunction in patients with or without diabetes mellitus and no history of significant coronary artery disease.

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