利用Alu插入分析Tacuarembó-Uruguay群体的遗传混合。

4区 生物学 Q2 Medicine
Yasser V Vega-Requena, Pedro C Hidalgo, Elizabeth Ackermann, Sara Flores-Gutierrez, Mónica Sans
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引用次数: 1

摘要

Tacuarembó是乌拉圭东北部的一个省,其人口是来自欧洲和近东的几次移民浪潮以及主要来自巴西的非洲人和非洲后裔的结果;这些海浪定居在该地区的各种土著民族(Charrúa, Minuán和Guaraní)。在过去,这个种群一直是遗传研究的焦点,显示出这种三杂交起源,土著和非洲人的贡献比乌拉圭其他地区更大。在这项研究中,我们分析了8个Alu插入(A25, ACE, APOA1, B65, D1, F13B, PV92, TPA25),为祖先和遗传分化提供了有价值的信息,并与Tacuarembó人群和其他乌拉圭人群的Alu频率研究进行了比较。欧洲人对Alu和经典标记的贡献与先前使用22种经典标记的研究几乎相等(63%对65%),而非洲人的贡献更高(30%对15%),美洲原住民的贡献在Alu上显示出重要差异:7%对20%。我们发现Tacuarembó和蒙得维的亚之间的遗传分化没有显著差异,但Tacuarembó和来自特立尼达的巴斯克后裔之间存在显著差异。我们的研究结果支持先前通过经典标记获得的发现,这些标记表明Tacuarembó种群的三杂交组成与历史记录相关。因此,Alu插入在乌拉圭人口的混合过程中提供了有趣的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic Admixture Analysis in the Population of Tacuarembó-Uruguay Using Alu Insertions.

Tacuarembó is a department located in northeastern Uruguay, whose population is the result of several migration waves from Europe and Near East, as well as Africans and Afro-descents mostly from Brazil; these waves settled with the territory's various Native ethnic groups (Charrúa, Minuán, and Guaraní). In the past, this population has been the focus of genetic studies showing this trihybrid origin, with greater contributions of Natives and Africans than in other Uruguayan regions. In this study we analyzed eight Alu insertions (A25, ACE, APOA1, B65, D1, F13B, PV92, TPA25) to provide valuable information for ancestrality and genetic differentiation and to compare with both previous studies on the Tacuarembó population and Alu frequencies in other Uruguayan populations. The European contribution to Alu and classical markers was almost equal to that of a previous study using 22 classical markers (63% vs. 65%), while African contribution was higher (30% vs. 15%), and Native American contribution shows an important difference in Alu: 7% versus 20%. We found no significant differences in genetic differentiation between Tacuarembó and Montevideo but significant differences between Tacuarembó and Basque descendants from Trinidad. Our results support previous findings obtained with classical markers that demonstrate the trihybrid composition of the Tacuarembó population, correlated with historical records. Thus, Alu insertions provide interesting information in light of the admixture process in the Uruguayan population.

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来源期刊
Human Biology
Human Biology 生物-生物学
CiteScore
1.90
自引率
0.00%
发文量
88
审稿时长
>12 weeks
期刊介绍: Human Biology publishes original scientific articles, brief communications, letters to the editor, and review articles on the general topic of biological anthropology. Our main focus is understanding human biological variation and human evolution through a broad range of approaches. We encourage investigators to submit any study on human biological diversity presented from an evolutionary or adaptive perspective. Priority will be given to interdisciplinary studies that seek to better explain the interaction between cultural processes and biological processes in our evolution. Methodological papers are also encouraged. Any computational approach intended to summarize cultural variation is encouraged. Studies that are essentially descriptive or concern only a limited geographic area are acceptable only when they have a wider relevance to understanding human biological variation. Manuscripts may cover any of the following disciplines, once the anthropological focus is apparent: human population genetics, evolutionary and genetic demography, quantitative genetics, evolutionary biology, ancient DNA studies, biological diversity interpreted in terms of adaptation (biometry, physical anthropology), and interdisciplinary research linking biological and cultural diversity (inferred from linguistic variability, ethnological diversity, archaeological evidence, etc.).
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