幽门螺杆菌与非酒精性脂肪肝

György M Buzás
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引用次数: 5

摘要

幽门螺杆菌是世界上最常见的感染,而非酒精性脂肪肝是最常见的肝脏疾病。常见的发生可能是偶然的,也可能是由于某些致病因素。流行病学研究表明,感染幽门螺杆菌的患者发生非酒精性肝病的风险增加。在人类肝癌和脂肪肝样本中很少发现幽门螺杆菌的DNA片段。幽门螺杆菌可能通过激素(胃促生长素)影响非酒精性脂肪肝的发展?胃泌激素?胰岛素?),或通过促炎细胞因子(白细胞介素1和8,肿瘤坏死因子,干扰素)的作用以及肠道微生物组的变化。补充益生菌可改善非酒精性脂肪肝的一些临床指标和幽门螺杆菌的根除率。尽管非酒精性脂肪肝会增加药物性肝损伤的风险,但用于根除的方案可以安全实施。有必要对根除对非酒精性脂肪肝的发展和进展的影响进行对照研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Helicobacter pylori and non-alcoholic fatty liver disease.

Helicobacter pylori is the most prevalent infection worldwide, while non-alcoholic fatty liver disease emerged as the most frequent liver disease. The common occurrence can be either by chance or due to certain pathogenetic factors. Epidemiologic studies revealed that the risk of non-alcoholic liver disease is increased in patients infected with Helicobacter pylori. DNA fragments of Helicobacter pylori were rarely identified in human samples of liver carcinoma and fatty liver. Helicobacter pylori could influence the development of non-alcoholic fatty liver either by hormonal (ghrelin? gastrin? insulin?), or by effect of pro-inflammatory cytokines (interleukin 1 and 8, tumor necrosis factor ɑ, interferon ɣ) and by changes of gut microbiome as well. Probiotic supplementation could improve some clinical parameters of non-alcoholic fatty liver disease and eradication rates of Helicobacter pylori. Regimens used for eradication can be safely administered, although non-alcoholic fatty liver increases the risk of drug-induced liver damage. Controlled studies of the effect of eradication on the development and progression of non-alcoholic fatty liver are warranted.

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