{"title":"漱口水对白色念珠菌和黏液红藻的抗真菌活性:一项体外研究","authors":"Rodrigo Alejandro Handschuh Briones , Evelyn Nicole Silva Arcos , Milton Urrutia , Patricio Godoy-Martínez","doi":"10.1016/j.riam.2019.10.006","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p><em>Candida albicans</em> and <em>Rhodotorula mucilaginosa</em> are yeasts of clinical importance in the oral cavity. In immunocompromised patients they can cause some pathologies that must be controlled with antimicrobials.</p></div><div><h3>Aims</h3><p>To evaluate and compare the antimicrobial efficacy of commercially available mouthrinses against strains of <em>C. albicans</em> and <em>R. mucilaginosa</em>.</p></div><div><h3>Methods</h3><p>The six mouthwashes studied <em>in vitro</em> were formulated (alone or in combination) with chlorhexidine (CHX) 0.12%, CHX 0.1%, CHX 0.05%, cetylpyridinium chloride (CPC) 0.075%, CPC 0.05%, and essential oils. Ten <em>C. albicans</em> and <em>R. mucilaginosa</em> isolates each were studied. The agar diffusion method (Mueller Hinton II), with incubation at 32<!--> <!-->°C was used to evaluate the antifungal activity.</p></div><div><h3>Results</h3><p>The results of this study indicate that mouthwashes with CHX 0.1%, CHX 0.12%, CHX 0.05% + CPC 0.05%, CHX 0.12% + CPC 0.05% and CPC 0.075% have an antifungal effect against <em>C. albicans</em> and <em>R. mucilaginosa</em>. CHX 0.1% led to the broadest inhibition zone for <em>C. albicans</em> and <em>R. mucilaginosa</em> (25.65<!--> <!-->±<!--> <!-->2.39<!--> <!-->mm and 40.05<!--> <!-->±<!--> <!-->3.31<!--> <!-->mm). Essential oils did not show any antifungal activity. Statistical analysis showed no statistical difference between mouth rinses CHX 0.1%, CHX 0.12% and CHX 0.12% + CPC 0.05% (<em>p</em> <!-->=<!--> <!-->0.0001) against <em>C. albicans</em> and <em>R. mucilaginosa</em>.</p></div><div><h3>Conclusions</h3><p>Mouthwashes with CHX showed higher antifungal activity against <em>C. albicans</em> and <em>R. mucilaginosa</em> than other mouthwashes studied.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.riam.2019.10.006","citationCount":"0","resultStr":"{\"title\":\"Actividad antifúngica de los enjuagues bucales frente a Candida albicans y Rhodotorula mucilaginosa: un estudio in vitro\",\"authors\":\"Rodrigo Alejandro Handschuh Briones , Evelyn Nicole Silva Arcos , Milton Urrutia , Patricio Godoy-Martínez\",\"doi\":\"10.1016/j.riam.2019.10.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p><em>Candida albicans</em> and <em>Rhodotorula mucilaginosa</em> are yeasts of clinical importance in the oral cavity. In immunocompromised patients they can cause some pathologies that must be controlled with antimicrobials.</p></div><div><h3>Aims</h3><p>To evaluate and compare the antimicrobial efficacy of commercially available mouthrinses against strains of <em>C. albicans</em> and <em>R. mucilaginosa</em>.</p></div><div><h3>Methods</h3><p>The six mouthwashes studied <em>in vitro</em> were formulated (alone or in combination) with chlorhexidine (CHX) 0.12%, CHX 0.1%, CHX 0.05%, cetylpyridinium chloride (CPC) 0.075%, CPC 0.05%, and essential oils. Ten <em>C. albicans</em> and <em>R. mucilaginosa</em> isolates each were studied. The agar diffusion method (Mueller Hinton II), with incubation at 32<!--> <!-->°C was used to evaluate the antifungal activity.</p></div><div><h3>Results</h3><p>The results of this study indicate that mouthwashes with CHX 0.1%, CHX 0.12%, CHX 0.05% + CPC 0.05%, CHX 0.12% + CPC 0.05% and CPC 0.075% have an antifungal effect against <em>C. albicans</em> and <em>R. mucilaginosa</em>. CHX 0.1% led to the broadest inhibition zone for <em>C. albicans</em> and <em>R. mucilaginosa</em> (25.65<!--> <!-->±<!--> <!-->2.39<!--> <!-->mm and 40.05<!--> <!-->±<!--> <!-->3.31<!--> <!-->mm). Essential oils did not show any antifungal activity. Statistical analysis showed no statistical difference between mouth rinses CHX 0.1%, CHX 0.12% and CHX 0.12% + CPC 0.05% (<em>p</em> <!-->=<!--> <!-->0.0001) against <em>C. albicans</em> and <em>R. mucilaginosa</em>.</p></div><div><h3>Conclusions</h3><p>Mouthwashes with CHX showed higher antifungal activity against <em>C. albicans</em> and <em>R. mucilaginosa</em> than other mouthwashes studied.</p></div>\",\"PeriodicalId\":21291,\"journal\":{\"name\":\"Revista Iberoamericana De Micologia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2020-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.riam.2019.10.006\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Iberoamericana De Micologia\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1130140620300024\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MYCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Iberoamericana De Micologia","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1130140620300024","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MYCOLOGY","Score":null,"Total":0}
Actividad antifúngica de los enjuagues bucales frente a Candida albicans y Rhodotorula mucilaginosa: un estudio in vitro
Background
Candida albicans and Rhodotorula mucilaginosa are yeasts of clinical importance in the oral cavity. In immunocompromised patients they can cause some pathologies that must be controlled with antimicrobials.
Aims
To evaluate and compare the antimicrobial efficacy of commercially available mouthrinses against strains of C. albicans and R. mucilaginosa.
Methods
The six mouthwashes studied in vitro were formulated (alone or in combination) with chlorhexidine (CHX) 0.12%, CHX 0.1%, CHX 0.05%, cetylpyridinium chloride (CPC) 0.075%, CPC 0.05%, and essential oils. Ten C. albicans and R. mucilaginosa isolates each were studied. The agar diffusion method (Mueller Hinton II), with incubation at 32 °C was used to evaluate the antifungal activity.
Results
The results of this study indicate that mouthwashes with CHX 0.1%, CHX 0.12%, CHX 0.05% + CPC 0.05%, CHX 0.12% + CPC 0.05% and CPC 0.075% have an antifungal effect against C. albicans and R. mucilaginosa. CHX 0.1% led to the broadest inhibition zone for C. albicans and R. mucilaginosa (25.65 ± 2.39 mm and 40.05 ± 3.31 mm). Essential oils did not show any antifungal activity. Statistical analysis showed no statistical difference between mouth rinses CHX 0.1%, CHX 0.12% and CHX 0.12% + CPC 0.05% (p = 0.0001) against C. albicans and R. mucilaginosa.
Conclusions
Mouthwashes with CHX showed higher antifungal activity against C. albicans and R. mucilaginosa than other mouthwashes studied.
期刊介绍：
Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.
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