Miquel Bioque , Karina S. Mac-Dowell , Cristina Font , Ana Meseguer , Elisabet Macau , Marta Garcia-Orellana , Marc Valentí , Juan C. Leza , Miquel Bernardo
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The aim of his study was to explore the acute effects of a single session of ECT on these neurotrophins signaling.</span></p><p>Plasma levels of BDNF and NGF and their tyrosine kinase-type receptors expression<span> in peripheral blood mononuclear cells (PBMCs) were determined before and two hours after a single ECT session in 30 subjects with a severe mental disorder.</span></p><p>Two hours after an ECT session we found a statistically significant decrease of BDNF plasma levels (<em>p</em> <!-->=<!--> <!-->0.007). We did not find significant acute effects on NGF plasma levels or receptors expression in PBMCs. We found a significant inverse correlation between the time of convulsion and BDNF plasma levels decrease (<em>r</em> <!-->=<!--> <!-->−0.041, <em>p</em> <!-->=<!--> <!-->0.024).</p><p>We have identified a decrease in BDNF plasma levels after 2<!--> <!-->h of a single ECT session. 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Previous studies have established the association between BDNF and NGF signaling and severe </span>mental disorders, but changes in BDNF plasma levels and </span>electroconvulsive therapy (ECT) response are controversial. The aim of his study was to explore the acute effects of a single session of ECT on these neurotrophins signaling.</span></p><p>Plasma levels of BDNF and NGF and their tyrosine kinase-type receptors expression<span> in peripheral blood mononuclear cells (PBMCs) were determined before and two hours after a single ECT session in 30 subjects with a severe mental disorder.</span></p><p>Two hours after an ECT session we found a statistically significant decrease of BDNF plasma levels (<em>p</em> <!-->=<!--> <!-->0.007). We did not find significant acute effects on NGF plasma levels or receptors expression in PBMCs. 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引用次数: 3
摘要
脑源性神经营养因子(BDNF)和神经生长因子(NGF)是在脑神经元功能中起重要作用的神经营养因子。先前的研究已经建立了BDNF和神经生长因子信号传导与严重精神障碍之间的联系，但BDNF血浆水平的变化和电休克治疗(ECT)反应存在争议。他的研究目的是探索单次电休克对这些神经营养因子信号的急性影响。对30例重度精神障碍患者进行单次ECT治疗前和治疗后2小时血浆BDNF和NGF水平及外周血单个核细胞(PBMCs)中酪氨酸激酶型受体的表达进行了测定。电休克治疗2小时后，我们发现血浆BDNF水平显著下降(p = 0.007)。我们没有发现对PBMCs中NGF血浆水平或受体表达的显著急性影响。我们发现惊厥时间与BDNF血浆水平下降呈显著负相关(r = - 0.041, p = 0.024)。我们发现单次ECT治疗2小时后血浆BDNF水平下降。这些结果表明，神经营养因子在电痉挛反应和安全性中的作用值得进一步研究。
Acute effects of a session of electroconvulsive therapy on brain-derived neurotrophic factor plasma levels
Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are neurotrophins that play critical roles in brain neuronal function. Previous studies have established the association between BDNF and NGF signaling and severe mental disorders, but changes in BDNF plasma levels and electroconvulsive therapy (ECT) response are controversial. The aim of his study was to explore the acute effects of a single session of ECT on these neurotrophins signaling.
Plasma levels of BDNF and NGF and their tyrosine kinase-type receptors expression in peripheral blood mononuclear cells (PBMCs) were determined before and two hours after a single ECT session in 30 subjects with a severe mental disorder.
Two hours after an ECT session we found a statistically significant decrease of BDNF plasma levels (p = 0.007). We did not find significant acute effects on NGF plasma levels or receptors expression in PBMCs. We found a significant inverse correlation between the time of convulsion and BDNF plasma levels decrease (r = −0.041, p = 0.024).
We have identified a decrease in BDNF plasma levels after 2 h of a single ECT session. These results indicate the interest for future research in the role of neurotrophins in the response and safety of ECT.
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