中、高脂肪膳食对多替格拉韦/利匹韦林固定剂量联合片生物利用度的影响。

IF 3.1 Q2 PHARMACOLOGY & PHARMACY

Clinical Pharmacology : Advances and Applications Pub Date : 2020-06-08 eCollection Date: 2020-01-01 DOI:10.2147/CPAA.S250751

Rashmi Mehta, Joseph Piscitelli, Allen Wolstenholme, Caifeng Fu, Herta Crauwels, Brian Wynne, Kimberly Adkison

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引用次数: 3

摘要

Dolutegravir 50mg (DTG)和rilpivirine 25mg (RPV)是一种新批准的治疗HIV病毒抑制患者的双药方案。本研究分为两部分，评价了五种DTG/RPV固定剂量联合片剂的相对生物利用度和食用效应。当给予中等或高脂肪膳食时，DTG和RPV的吸收都增加了，导致更高的暴露。根据产品标签，DTG/RPV / FDC应随餐服用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The Effect of Moderate- and High-Fat Meals on the Bioavailability of Dolutegravir/Rilpivirine Fixed-Dose Combination Tablet.

查看原文本刊更多论文

The Effect of Moderate- and High-Fat Meals on the Bioavailability of Dolutegravir/Rilpivirine Fixed-Dose Combination Tablet.

Dolutegravir 50 mg (DTG) and rilpivirine 25 mg (RPV) are a newly approved 2-drug regimen for the treatment of HIV in virally suppressed patients. A 2-part study evaluated the relative bioavailability and food effect of five experimental fixed-dose combination (FDC) tablet formulations of DTG/RPV. When given with a moderate- or high-fat meal, the absorption of both DTG and RPV was increased, resulting in higher exposures. As per product labelling, DTG/RPV FDC should be taken with a meal.

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来源期刊

Clinical Pharmacology : Advances and Applications PHARMACOLOGY & PHARMACY-

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

16 weeks