静止与细胞增殖交叉路口的限制点调控。

IF 3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Betheney R Pennycook, Alexis R Barr
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引用次数: 0

摘要

细胞增殖与细胞周期可逆地退出静止期之间的协调对于多细胞生物体的发育和成人组织的平衡至关重要。细胞在静止和增殖之间的抉择发生在限制点,人们普遍认为限制点位于细胞周期的 G1 阶段,此时细胞会整合积累的细胞外和细胞内信号,以驱动这种二元细胞决策。在分子水平上,决策是通过激活细胞周期蛋白依赖性激酶(CDKs)来实现的。CDK 磷酸化视网膜母细胞瘤(Rb)转录抑制因子,从而调节细胞周期基因的表达。最近,限制点调控的经典观点受到了挑战。在此,我们回顾了有关 CDK 的活化、Rb 磷酸化以及细胞周期中限制点的性质和位置的最新发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Restriction point regulation at the crossroads between quiescence and cell proliferation.

The coordination of cell proliferation with reversible cell cycle exit into quiescence is crucial for the development of multicellular organisms and for tissue homeostasis in the adult. The decision between quiescence and proliferation occurs at the restriction point, which is widely thought to be located in the G1 phase of the cell cycle, when cells integrate accumulated extracellular and intracellular signals to drive this binary cellular decision. On the molecular level, decision-making is exerted through the activation of cyclin-dependent kinases (CDKs). CDKs phosphorylate the retinoblastoma (Rb) transcriptional repressor to regulate the expression of cell cycle genes. Recently, the classical view of restriction point regulation has been challenged. Here, we review the latest findings on the activation of CDKs, Rb phosphorylation and the nature and position of the restriction point within the cell cycle.

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来源期刊
FEBS Letters
FEBS Letters 生物-生化与分子生物学
CiteScore
6.60
自引率
2.90%
发文量
303
审稿时长
1 months
期刊介绍: FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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