聚酮和非核糖体肽生物合成的标记研究

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2023-01-01 DOI:10.1039/d2np00071g

Anwei Hou , Jeroen S. Dickschat

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引用次数: 0

摘要

涵盖：2015年至2022年在这篇综述中，我们讨论了使用同位素标记化合物研究聚酮、非核糖体合成肽及其杂交体生物合成的最新进展。此外，我们还强调了同位素在阐明其结构和研究酶机制方面的应用。详细介绍了所选实例的生物合成途径，以揭示所讨论的标记实验的原理。所提供的实例表明同位素标记化合物的应用仍然是现有技术的状态，并且可以为天然产物的生物合成提供有价值的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides

查看原文本刊更多论文

Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides

Covering: 2015 to 2022

In this review, we discuss the recent advances in the use of isotopically labelled compounds to investigate the biosynthesis of polyketides, non-ribosomally synthesised peptides, and their hybrids. Also, we highlight the use of isotopes in the elucidation of their structures and investigation of enzyme mechanisms. The biosynthetic pathways of selected examples are presented in detail to reveal the principles of the discussed labelling experiments. The presented examples demonstrate that the application of isotopically labelled compounds is still the state of the art and can provide valuable information for the biosynthesis of natural products.

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.