微生物生产的工程运输系统。

2区生物学 Q1 Immunology and Microbiology

Advances in applied microbiology Pub Date : 2020-01-01 Epub Date: 2020-02-08 DOI:10.1016/bs.aambs.2020.01.002

Moses Onyeabor, Rodrigo Martinez, Gavin Kurgan, Xuan Wang

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引用次数: 7

摘要

代谢工程领域的快速发展使得代谢途径的复杂修改能够产生多样化的产品组合。控制底物吸收和产物输出是代谢工程的一个重要研究领域。运输系统的优化有可能提高可再生燃料和化学品的微生物生产。本章全面回顾了对微生物生产至关重要的运输系统，以及目前改善运输功能和生产指标的基因工程策略。此外，本章重点介绍了工程微生物外排系统的最新进展，以提高细胞对工业相关化学应激的耐受性。最后，讨论了解决当前技术差距的未来方向。

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Engineering transport systems for microbial production.

The rapid development in the field of metabolic engineering has enabled complex modifications of metabolic pathways to generate a diverse product portfolio. Manipulating substrate uptake and product export is an important research area in metabolic engineering. Optimization of transport systems has the potential to enhance microbial production of renewable fuels and chemicals. This chapter comprehensively reviews the transport systems critical for microbial production as well as current genetic engineering strategies to improve transport functions and thus production metrics. In addition, this chapter highlights recent advancements in engineering microbial efflux systems to enhance cellular tolerance to industrially relevant chemical stress. Lastly, future directions to address current technological gaps are discussed.

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来源期刊

Advances in applied microbiology 生物-生物工程与应用微生物

CiteScore

8.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Advances in Applied Microbiology offers intensive reviews of the latest techniques and discoveries in this rapidly moving field. The editors are recognized experts and the format is comprehensive and instructive. Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology. Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays.