建立多学科团队治疗特发性肉芽肿性乳腺炎在改善患者预后和传播对近期疾病趋势的认识中的作用

IF 1.6 Q4 ONCOLOGY
International Journal of Breast Cancer Pub Date : 2020-01-27 eCollection Date: 2020-01-01 DOI:10.1155/2020/5243958
Rami J Yaghan, Nehad M Ayoub, Shadi Hamouri, Alia Al-Mohtaseb, Maha Gharaibeh, Lamees Yaghan, Mahmoud Al-Dari, Hiba Al-Kaff, Nabil A Al-Zoubi
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引用次数: 5

摘要

背景:特发性肉芽肿性乳腺炎(IGM)被刻板地描述为一种神秘的实体,它模仿乳腺癌,给管理带来挑战。2002年,我们建立了一个多学科团队来治疗IGM患者。本研究旨在评估该团队在改善患者预后方面的作用。此外,文献综述提供了强调最近的疾病趋势。患者和方法。分析了2002年至2018年44例IGM患者的相关数据,并与2002年之前的数据进行了比较。结果:平均诊断年龄37.9岁±6.4岁。经真切活检(True-cut biopsy, TCB)、冷冻切片(Frozen切片,FS)和手术活检确诊IGM的患者分别为70.5%、25%和4.5%。FS用于评估3例患者的切除边缘。39份超声报告中有1份,20份乳房x光检查报告中有1份怀疑是恶性肿瘤。广泛局部切除是主要的治疗方式(95.5%)。19例患者(43.2%)接受皮质类固醇治疗。在2002年之前,IGM仅在手术切除后才被识别,71%的患者最初误以为是癌。2002年以后,临床对癌的初次假印象下降到29.5%。复发率为31.82%。诊断时年龄较轻与复发有显著相关性(χ 2 = 5.598;P = 0.018)。卡方分析显示BMI与复发率无显著相关性(χ 2 = 0.776;P = 0.678)。结论:多学科IGM团队的建立与减少乳腺癌的错误印象和减少乳腺癌的假阳性放射诊断有关。FS是一个有用的验证程序。我们的系列包括第一例弥漫性丘疹作为IGM的系统性表现。最近的文献表明,IGM正在改变它的面貌。IGM在所有年龄组,甚至在男性中都有报道。临床表现明显扩大。TCB诊断已经取代了盲目的手术切除。关于复发预测因素的更多数据正在积累。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Role of Establishing a Multidisciplinary Team for Idiopathic Granulomatous Mastitis in Improving Patient Outcomes and Spreading Awareness about Recent Disease Trends.

The Role of Establishing a Multidisciplinary Team for Idiopathic Granulomatous Mastitis in Improving Patient Outcomes and Spreading Awareness about Recent Disease Trends.

The Role of Establishing a Multidisciplinary Team for Idiopathic Granulomatous Mastitis in Improving Patient Outcomes and Spreading Awareness about Recent Disease Trends.

Background: Iidiopathic granulomatous mastitis (IGM) is stereotypically described as a mysterious entity that mimics breast carcinoma imposing management challenges. In 2002, we established a multidisciplinary team to treat patients with IGM. This study aimed to evaluate the role of this team in improving patient outcomes. Also, a review of literature is provided to highlight recent disease trends. Patients and Methods. Pertinent data for 44 patients treated for IGM from 2002 to 2018 were analyzed and compared to data prior to 2002.

Results: Mean age at diagnosis was 37.9 years ± 6.4. The diagnosis of IGM was confirmed by True-cut biopsy (TCB), Frozen section (FS), and surgical biopsy in 70.5%, 25%, and 4.5% of patients, respectively. FS was used to assess the resection margins in three patients. Suspicion for malignancy was raised in one out of 39 ultrasound reports, and one out of 20 mammography reports. Wide local excision was the main treatment modality (95.5%). 19 patients (43.2%) received corticosteroids. Prior to 2002, IGM was only recognized after surgical resection with a 71% initial false impression of carcinoma. After 2002, the initial false clinical impression of carcinoma dropped to 29.5%. Recurrence rate was 31.82%. Younger age at diagnosis was significantly associated with recurrence (χ 2 = 5.598; p = 0.018). Chi-square analysis showed no significant association between BMI and recurrence (χ 2 = 0.776; p = 0.678).

Conclusion: The establishment of a multidisciplinary team for IGM was associated with a reduced erroneous impression of breast cancer, and a reduced false positive radiological diagnosis of breast carcinoma. FS was a useful confirmatory procedure. Our series included the first case of a diffuse papular rash as a systemic manifestation of IGM. Recent literature indicates that IGM is changing its face. IGM is being reported in all age groups, and even in males. The clinical manifestations have markedly expanded. Diagnosis by TCB has replaced blind surgical excision. More data regarding predictors of recurrence is accumulating.

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来源期刊
CiteScore
3.40
自引率
0.00%
发文量
25
审稿时长
19 weeks
期刊介绍: International Journal of Breast Cancer is a peer-reviewed, Open Access journal that provides a forum for scientists, clinicians, and health care professionals working in breast cancer research and management. The journal publishes original research articles, review articles, and clinical studies related to molecular pathology, genomics, genetic predisposition, screening and diagnosis, disease markers, drug sensitivity and resistance, as well as novel therapies, with a specific focus on molecular targeted agents and immune therapies.
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