基于姜黄的口腔冲洗液“HTOR-091516”改善实验性口腔黏膜炎。

Ayu Pub Date : 2019-04-01 Epub Date: 2020-03-20 DOI:10.4103/ayu.AYU_282_18
Suryakanth Dattatreya Anturlikar, Mohammed Mukhram Azeemuddin, Sandeep Varma, Onkaramurthy Mallappa, Dilip Niranjan, Ashok Basti Krishnaiah, Shruthi Manjunath Hegde, Mohamed Rafiq, Rangesh Paramesh
{"title":"基于姜黄的口腔冲洗液“HTOR-091516”改善实验性口腔黏膜炎。","authors":"Suryakanth Dattatreya Anturlikar,&nbsp;Mohammed Mukhram Azeemuddin,&nbsp;Sandeep Varma,&nbsp;Onkaramurthy Mallappa,&nbsp;Dilip Niranjan,&nbsp;Ashok Basti Krishnaiah,&nbsp;Shruthi Manjunath Hegde,&nbsp;Mohamed Rafiq,&nbsp;Rangesh Paramesh","doi":"10.4103/ayu.AYU_282_18","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Prevalence and incidence of oral mucositis (OM) are rigorously increasing and there is no effective treatment. The herbal formulation \"HTOR-091516\" containing <i>Curcuma longa</i>, <i>Triphala</i> and honey were evaluated for the treatment of OM.</p><p><strong>Aim: </strong>The aim of this study was to evaluate the safety and efficacy of HTOR-091516, employing cellular model, human gingival fibroblasts-1 (HGF-1), and 5-fluorouracil (5-FU)-induced mucositis model in rats.</p><p><strong>Materials and methods: </strong>The cell viability was assessed using 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay and the inhibitory effect of HTOR-091516 on tumor necrosis factor-alpha (TNF-α) was evaluated using TNF-α bioassay in lipopolysaccharides-induced HGF-1. 5-FU and glacial acetic acid were used to induce OM in rats. Animals were divided into two groups, group 1 served as mucositis control and group 2 was treated with HTOR-091516 at the dose of 200 μl and TNF-α was estimated in plasma samples.</p><p><strong>Results: </strong>The <i>in vitro</i> safety of HTOR-091516 was evaluated in reconstructed human oral epidermis and was found to be nontoxic and exhibited concentration-dependent TNF-α inhibition in HGF-1. The treatment with HTOR-091516 reduced mucositis scores and mortality rate and also decreased the plasma TNF-α level.</p><p><strong>Conclusion: </strong>The present data indicate that HTOR-091516 is effective in the treatment of OM.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/ce/AYU-40-127.PMC7210821.pdf","citationCount":"2","resultStr":"{\"title\":\"Turmeric based oral rinse \\\"HTOR-091516\\\" ameliorates experimental oral mucositis.\",\"authors\":\"Suryakanth Dattatreya Anturlikar,&nbsp;Mohammed Mukhram Azeemuddin,&nbsp;Sandeep Varma,&nbsp;Onkaramurthy Mallappa,&nbsp;Dilip Niranjan,&nbsp;Ashok Basti Krishnaiah,&nbsp;Shruthi Manjunath Hegde,&nbsp;Mohamed Rafiq,&nbsp;Rangesh Paramesh\",\"doi\":\"10.4103/ayu.AYU_282_18\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Prevalence and incidence of oral mucositis (OM) are rigorously increasing and there is no effective treatment. The herbal formulation \\\"HTOR-091516\\\" containing <i>Curcuma longa</i>, <i>Triphala</i> and honey were evaluated for the treatment of OM.</p><p><strong>Aim: </strong>The aim of this study was to evaluate the safety and efficacy of HTOR-091516, employing cellular model, human gingival fibroblasts-1 (HGF-1), and 5-fluorouracil (5-FU)-induced mucositis model in rats.</p><p><strong>Materials and methods: </strong>The cell viability was assessed using 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay and the inhibitory effect of HTOR-091516 on tumor necrosis factor-alpha (TNF-α) was evaluated using TNF-α bioassay in lipopolysaccharides-induced HGF-1. 5-FU and glacial acetic acid were used to induce OM in rats. Animals were divided into two groups, group 1 served as mucositis control and group 2 was treated with HTOR-091516 at the dose of 200 μl and TNF-α was estimated in plasma samples.</p><p><strong>Results: </strong>The <i>in vitro</i> safety of HTOR-091516 was evaluated in reconstructed human oral epidermis and was found to be nontoxic and exhibited concentration-dependent TNF-α inhibition in HGF-1. The treatment with HTOR-091516 reduced mucositis scores and mortality rate and also decreased the plasma TNF-α level.</p><p><strong>Conclusion: </strong>The present data indicate that HTOR-091516 is effective in the treatment of OM.</p>\",\"PeriodicalId\":8720,\"journal\":{\"name\":\"Ayu\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/ce/AYU-40-127.PMC7210821.pdf\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ayu\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ayu.AYU_282_18\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/3/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ayu","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ayu.AYU_282_18","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/3/20 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

摘要

背景:口腔黏膜炎(OM)的患病率和发病率正在急剧上升,目前尚无有效的治疗方法。对含姜黄、Triphala、蜂蜜的中药制剂HTOR-091516治疗OM的疗效进行了评价。目的:采用细胞模型、人牙龈成纤维细胞-1 (HGF-1)和5-氟尿嘧啶(5-FU)诱导大鼠粘膜炎模型,评价HTOR-091516的安全性和有效性。材料与方法:采用3-(4,5 -二甲基噻唑-2)- 2,5 -二苯基溴化四唑(MTT)法测定细胞活力,采用TNF-α生物测定法测定HTOR-091516对脂多糖诱导的HGF-1的抑制作用。用5-FU和冰醋酸诱导大鼠OM。将动物分为两组,1组作为黏膜炎对照组,2组用200 μl剂量的HTOR-091516治疗,测定血浆样品中TNF-α的含量。结果:HTOR-091516体外安全性在重建的人口腔表皮中进行了评估,发现其无毒且对HGF-1具有浓度依赖性的TNF-α抑制作用。HTOR-091516治疗可降低黏膜炎评分和死亡率,降低血浆TNF-α水平。结论:HTOR-091516治疗OM有较好的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Turmeric based oral rinse "HTOR-091516" ameliorates experimental oral mucositis.

Turmeric based oral rinse "HTOR-091516" ameliorates experimental oral mucositis.

Turmeric based oral rinse "HTOR-091516" ameliorates experimental oral mucositis.

Turmeric based oral rinse "HTOR-091516" ameliorates experimental oral mucositis.

Background: Prevalence and incidence of oral mucositis (OM) are rigorously increasing and there is no effective treatment. The herbal formulation "HTOR-091516" containing Curcuma longa, Triphala and honey were evaluated for the treatment of OM.

Aim: The aim of this study was to evaluate the safety and efficacy of HTOR-091516, employing cellular model, human gingival fibroblasts-1 (HGF-1), and 5-fluorouracil (5-FU)-induced mucositis model in rats.

Materials and methods: The cell viability was assessed using 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay and the inhibitory effect of HTOR-091516 on tumor necrosis factor-alpha (TNF-α) was evaluated using TNF-α bioassay in lipopolysaccharides-induced HGF-1. 5-FU and glacial acetic acid were used to induce OM in rats. Animals were divided into two groups, group 1 served as mucositis control and group 2 was treated with HTOR-091516 at the dose of 200 μl and TNF-α was estimated in plasma samples.

Results: The in vitro safety of HTOR-091516 was evaluated in reconstructed human oral epidermis and was found to be nontoxic and exhibited concentration-dependent TNF-α inhibition in HGF-1. The treatment with HTOR-091516 reduced mucositis scores and mortality rate and also decreased the plasma TNF-α level.

Conclusion: The present data indicate that HTOR-091516 is effective in the treatment of OM.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Ayu
Ayu
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信