Axin2+子宫内膜干细胞:子宫内膜再生和癌症的来源。

Molecular & cellular oncology Pub Date : 2020-03-05 eCollection Date: 2020-01-01 DOI:10.1080/23723556.2020.1729681
Shafiq M Syed, Pradeep S Tanwar
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引用次数: 7

摘要

月经是灵长类动物的基本生命过程之一,但人们对其了解甚少。在此期间,雌性子宫内膜每个月都会脱落,但在一周内就会完全再生。60多年来,关于干细胞的存在和/或身份的明确证据一直难以捉摸。最近,我们报道了一个经典的Wnt报告基因Axin2作为子宫内膜干细胞的标记物,也作为子宫内膜癌的起源细胞。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Axin2+ endometrial stem cells: the source of endometrial regeneration and cancer.

Menstruation is one of the basic but poorly understood life processes in primates during which females shed inner uterine lining every month only to be completely regenerated back within a week. The definitive evidence for the existence and/or identity of stem cells responsible for this process has remained elusive for more than six decades now. Recently, we reported Axin2, a classical Wnt reporter gene, as a marker for endometrial stem cells that also serve as the cells of origin for endometrial cancer.

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