利用循环肿瘤细胞鉴定去势抵抗性前列腺癌耐药机制的前景:上皮细胞到间质细胞的转化是关键因素吗?

IF 2.3 Q3 ONCOLOGY
Prostate Cancer Pub Date : 2020-03-30 eCollection Date: 2020-01-01 DOI:10.1155/2020/7938280
Tanzila Khan, Kieran F Scott, Therese M Becker, John Lock, Mohammed Nimir, Yafeng Ma, Paul de Souza
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引用次数: 12

摘要

前列腺癌(PCa)最初是由过多的雄激素受体(AR)信号驱动的,雄激素剥夺疗法(ADT)是治疗前列腺癌的主要治疗方法。然而,耐药性的发展对一线和最近开发的二线ADTs的有效性都是一个重大限制。因此,有必要在其他可能介导这种耐药性的致癌信号通路的背景下研究AR信号。本综述的重点是转移性去势抵抗性前列腺癌中AR信号通路、众所周知的磷脂酰肌醇-3激酶/AKT通路以及这些通路的新兴介质Hippo/YAP1轴之间的相互作用,以及它们参与上皮-间质转化(EMT)的调节,EMT是疾病进展和ADT抵抗的一个特征。对循环肿瘤细胞(CTCs)中这些通路的分析可能提供一个机会来评估它们作为生物标志物的效用,并解决它们在当前ADT耐药性发展中的重要性,并有可能指导未来的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?

The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?

The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?

The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?

Prostate cancer (PCa) is initially driven by excessive androgen receptor (AR) signaling with androgen deprivation therapy (ADT) being a major therapeutic approach to its treatment. However, the development of drug resistance is a significant limitation on the effectiveness of both first-line and more recently developed second-line ADTs. There is a need then to study AR signaling within the context of other oncogenic signaling pathways that likely mediate this resistance. This review focuses on interactions between AR signaling, the well-known phosphatidylinositol-3-kinase/AKT pathway, and an emerging mediator of these pathways, the Hippo/YAP1 axis in metastatic castrate-resistant PCa, and their involvement in the regulation of epithelial-mesenchymal transition (EMT), a feature of disease progression and ADT resistance. Analysis of these pathways in circulating tumor cells (CTCs) may provide an opportunity to evaluate their utility as biomarkers and address their importance in the development of resistance to current ADT with potential to guide future therapies.

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来源期刊
Prostate Cancer
Prostate Cancer ONCOLOGY-
CiteScore
2.70
自引率
0.00%
发文量
9
审稿时长
13 weeks
期刊介绍: Prostate Cancer is a peer-reviewed, Open Access journal that provides a multidisciplinary platform for scientists, surgeons, oncologists and clinicians working on prostate cancer. The journal publishes original research articles, review articles, and clinical studies related to the diagnosis, surgery, radiotherapy, drug discovery and medical management of the disease.
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