阻断临床相关人类分离的多氏拟杆菌淀粉利用系统的非致死性生长抑制。

IF 3.597 Q2 Pharmacology, Toxicology and Pharmaceutics

MedChemComm Pub Date : 2019-07-05 eCollection Date: 2019-11-01 DOI:10.1039/c9md00301k

Anthony D Santilli, Jordan T Russell, Eric W Triplett, Kristi J Whitehead, Daniel C Whitehead

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引用次数: 6

摘要

我们描述了用小分子探针阿卡波糖以非致死方式抑制属于不同菌株的多氏拟杆菌的淀粉利用系统(Sus)。低至5 μM浓度的阿卡波糖显著抑制了dorei的生长，增加了培养的倍增时间。这种拟杆菌的成功抑制与包括I型糖尿病在内的几种疾病状态有关。这种方法继续探索一种新的、潜在的途径，通过对其成分的战略性操纵来干预与人类肠道微生物群组成异常变化相关的疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Non-lethal growth inhibition by arresting the starch utilization system of clinically relevant human isolates of Bacteroides dorei.

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Non-lethal growth inhibition by arresting the starch utilization system of clinically relevant human isolates of Bacteroides dorei.

We describe the inhibition of the starch utilization system (Sus) belonging to various strains of Bacteroides dorei in a non-lethal manner using the small molecule probe, acarbose. Concentrations of acarbose as low as 5 μM significantly impede the growth of B. dorei and increase the doubling time of cultures. The successful inhibition of this species of Bacteroides is relevant to several disease states including type I diabetes mellitus. This method continues to explore a new, potential route to intervene in illnesses associated with aberrant changes in the composition of the human gut microbiota through the strategic manipulation of its constituents.

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来源期刊

MedChemComm BIOCHEMISTRY & MOLECULAR BIOLOGY-CHEMISTRY, MEDICINAL

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

2.2 months

期刊介绍： Research and review articles in medicinal chemistry and related drug discovery science; the official journal of the European Federation for Medicinal Chemistry. In 2020, MedChemComm will change its name to RSC Medicinal Chemistry. Issue 12, 2019 will be the last issue as MedChemComm.