GLP-1受体基因多态性与奖励学习、快感缺乏和抑郁症诊断的关系

IF 2.6 4区 医学 Q3 NEUROSCIENCES
Acta Neuropsychiatrica Pub Date : 2020-08-01 Epub Date: 2020-03-26 DOI:10.1017/neu.2020.14
Hale Yapici-Eser, Vivek Appadurai, Candan Yasemin Eren, Dilek Yazici, Chia-Yen Chen, Dost Öngür, Diego A Pizzagalli, Thomas Werge, Mei-Hua Hall
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引用次数: 8

摘要

背景:胰高血糖素样肽-1受体(GLP-1Rs)在大脑中广泛表达。有证据表明,它们可能在奖励反应和神经保护中发挥作用。然而,GLP-1R与快感缺乏和抑郁诊断的关系尚未得到研究。在这里,我们研究了GLP-1R多态性与快感缺乏的客观和主观测量以及抑郁症诊断的关系。方法:收集麦克林医院100名对照者和164名患者的临床变量和DNA样本,采用概率奖励任务(PRT)评估客观[反应偏倚]和主观[Snaith-Hamilton快乐量表(SHAPS)]测量快感缺乏症。作为精神病学基因组学联盟(PGC)的一部分,一个独立的样本基因分型被用来研究与PRT反应偏倚相关的GLP-1R多态性对抑郁症诊断的影响。结果:在控制年龄、性别、病例对照状态和PRT判别性的情况下,rs1042044的C等位基因与PRT反应偏倚增加显著相关。基于SHAPS评分,rs1042044的AA基因型表现出更高的快感缺乏表型。然而,PGC重度抑郁症数据分析显示rs1042044与抑郁症诊断无关联。结论:研究结果提示rs1042044可能与快感缺乏有关,但与抑郁症诊断无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis.

Background: Glucagon-like peptide-1 receptors (GLP-1Rs) are widely expressed in the brain. Evidence suggests that they may play a role in reward responses and neuroprotection. However, the association of GLP-1R with anhedonia and depression diagnosis has not been studied. Here, we examined the association of GLP-1R polymorphisms with objective and subjective measures of anhedonia, as well as depression diagnosis.

Methods: Objective [response bias assessed by the probabilistic reward task (PRT)] and subjective [Snaith-Hamilton Pleasure Scale (SHAPS)] measures of anhedonia, clinical variables and DNA samples were collected from 100 controls and 164 patients at McLean Hospital. An independent sample genotyped as part of the Psychiatric Genomics Consortium (PGC) was used to study the effect of putative GLP-1R polymorphisms linked to response bias in PRT on depression diagnosis.

Results: The C allele in rs1042044 was significantly associated with increased PRT response bias, when controlling for age, sex, case-control status and PRT discriminability. AA genotype of rs1042044 showed higher anhedonia phenotype based on SHAPS scores. However, analysis of PGC major depressive disorder data showed no association between rs1042044 and depression diagnosis.

Conclusion: Findings suggest a possible association of rs1042044 with anhedonia but no association with depression diagnosis.

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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica NEUROSCIENCES-PSYCHIATRY
自引率
5.30%
发文量
30
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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